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ACTH Recombinant monoclonal antibody (r57)

ENZ-ABS319-0100 100 µg 397.00 USD
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Product Specification

Alternative Name:Adrenocorticotropic hormone, Corticotropin
Immunogen:An N-terminal peptide (within aa 1-24) from the Synacthen/ACTH region of human POMC.
UniProt ID:P01189
Species reactivity:Human, Mouse, Rat
Specificity:This mAb is specific to Synacthen (aa 1-24 of ACTH); does not cross-react with CLIP (aa 17-39 of ACTH).
Applications:IHC (PS)
Recommended Dilutions/Conditions:Immunohistochemistry (formalin-fixed paraffin sections) (0.5-1 µg/mL) for 30 minutes at RT
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide.
Shipping:Shipped on Blue Ice
Long Term Storage:+4°C
Scientific Background:ACTH (adrenocorticotropic hormone, corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, α-MSH (melanocyte stimulating hormone), β-MSH, γ-MSH, CLIP (corticotropin-like intermediary peptide), lipotropin-β, lipotropin-γ, β-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

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