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CFTR Recombinant monoclonal antibody (CFTR/1775R)

 
ENZ-ABS310-0100 100 µg 440.00 USD
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Product Specification

Alternative Name:Cystic fibrosis transmembrane conductance regulator, ABCC7
 
Clone:CFTR/1775R
 
Host:Rabbit
 
Isotype:IgGκ
 
Immunogen:Recombinant human CFTR (aa 258-385).
 
UniProt ID:P13569
 
Gene/Protein Identifier:1080 (Gene ID)
 
Species reactivity:Human
 
Applications:IF, IHC (PS)
 
Recommended Dilutions/Conditions:Immunofluorescence (0.5-1 µg/mL)
Immunohistochemistry (formalin-fixed paraffin sections) (1-2 µg/mL for 30 min at RT)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Scientific Background:CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
 

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