| ENZ-ABS295-0100 | 100 µg | 392.00 USD |  |
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| Alternative Name: | Apolipoprotein E4 |
| Clone: | 4E4 |
| Host: | Mouse |
| Isotype: | IgG1κ |
| Immunogen: | Synthetic peptide corresponding to residues surrounding Arg110 of human ApoE4 protein. |
| UniProt ID: | P02649 |
| Source: | Purified from ascites. |
| Species reactivity: | Human |
| Specificity: | Recognizes endogenous levels of total ApoE4 protein. |
| Crossreactivity: | Does not cross-react with ApoE2 or ApoE3. |
| Applications: | ELISA, IP, WB |
| Recommended Dilutions/Conditions: | Western Blot (1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein G affinity purified. |
| Formulation: | Liquid. In PBS containing 50% glycerol and 0.09% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Apolipoproteins are plasma lipoproteins that function as transporters of lipids and cholesterol in the circulatory system. Human ApoE is an apolipoprotein that has three isoforms: ApoE2, ApoE3, and ApoE4. The ApoE4 variant is the largest known genetic risk factor for late-onset Alzheimer's disease, and while the exact mechanism remains to be determined, it appears there may be an interaction with beta-amyloid. Alzheimer's disease is characterized by build-ups of aggregates of the peptide beta-amyloid. Apolipoprotein E enhances proteolytic break-down of this peptide, both within and between cells. The isoform ApoE4 is not as effective as the others at promoting these reactions, resulting in increased vulnerability to AD in individuals with that gene variation. |
| Regulatory Status: | RUO - Research Use Only |
ApoE ELISA kit |
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| Highly sensitive ApoE ELISA kit enabling detection of ApoE in serum, plasma, cell culture supernates, and tissue homogenates in 3.5 hours. | ||||||
| ELISA, Colorimetric detection | Print as PDF | ||||||
| ENZ-KIT134-0001 | 96 wells | 796.00 USD | |
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