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ApoE4 monoclonal antibody (4E4)

 
ENZ-ABS295-0100 100 µg 296.00 USD
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Product Specification

Alternative Name:Apolipoprotein E4
 
Clone:4E4
 
Host:Mouse
 
Isotype:IgG1κ
 
Immunogen:Synthetic peptide corresponding to residues surrounding Arg110 of human ApoE4 protein.
 
UniProt ID:P02649
 
Species reactivity:Human
 
Specificity:Recognizes endogenous levels of total ApoE4 protein.
 
Crossreactivity:Does not cross-react with ApoE2 or ApoE3.
 
Applications:ELISA, IP, WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Apolipoproteins are plasma lipoproteins that function as transporters of lipids and cholesterol in the circulatory system. Human ApoE is an apolipoprotein that has three isoforms: ApoE2, ApoE3, and ApoE4.

The ApoE4 variant is the largest known genetic risk factor for late-onset Alzheimer's disease, and while the exact mechanism remains to be determined, it appears there may be an interaction with beta-amyloid. Alzheimer's disease is characterized by build-ups of aggregates of the peptide beta-amyloid. Apolipoprotein E enhances proteolytic break-down of this peptide, both within and between cells. The isoform ApoE4 is not as effective as the others at promoting these reactions, resulting in increased vulnerability to AD in individuals with that gene variation.
 
ENZ-ABS295 WB
Figure 1. Western blot of ApoE4, mAb (4E4) (Prod. No. ENZ-ABS295). αApoE4 4E4: Mouse monoclonal antibody 4E4 specific for ApoE4, cell culture supernatant.
αPan ApoE: Rabbit polyclonal serum recognizing all three ApoE proteins.
ENZ-ABS295 IP
Figure 2. Immunoprecipitation. ApoE4, mAb (4E4) immunoprecipitates specifically ApoE4 but not ApoE2 or ApoE3.
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ENZ-ABS295 WB ENZ-ABS295 IP

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