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Polycomb 2 polyclonal antibody

 
ENZ-ABS291-0100 100 µl 250.00 USD
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Product Specification

Alternative Name:E3 SUMO-protein Ligase CBX4, Chromobox Protein Homolog 4, Pc2
 
Host:Rabbit
 
Isotype:IgG
 
Immunogen:Synthetic peptide corresponding to a portion of N-terminal human Polycomb 2, conjugated to KLH.
 
UniProt ID:O00257
 
Species reactivity:Human, Mouse
 
Applications:ELISA, IHC, WB
 
Recommended Dilutions/Conditions:ELISA (1:1,000)
Immunohistochemistry (1:50-1:100)
Western Blot (1:100-1:500)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Affinity purified
 
Formulation:Liquid. In PBS containing 0.09% sodium azide.
 
Use/Stability:Aliquots are stable for at least 12 months.
 
Handling:Avoid freeze/thaw cycles, aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:Polycomb 2 is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of proper expression patterns of developmental master regulators; changes in expression pf PcG proteins have been associated with cancer. Polycomb 2 is a part of the cellular memory system responsible for the inheritance of gene activity by progeny cells. It participates in maintaining the transcriptionally repressive state of genes. Polycomb 2 is part of acomplex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Polycomb 2 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I.
 

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