| ENZ-ABS291-0100 | 100 µl | 360.00 USD |  |
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| Alternative Name: | E3 SUMO-protein Ligase CBX4, Chromobox Protein Homolog 4, Pc2 |
| Host: | Rabbit |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide corresponding to a portion of N-terminal human Polycomb 2, conjugated to KLH. |
| UniProt ID: | O00257 |
| Species reactivity: | Human, Mouse |
| Applications: | ELISA, IHC, WB |
| Recommended Dilutions/Conditions: | ELISA (1:1,000) Immunohistochemistry (1:50-1:100) Western Blot (1:100-1:500) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Affinity purified |
| Formulation: | Liquid. In PBS containing 0.09% sodium azide. |
| Use/Stability: | Aliquots are stable for at least 12 months. |
| Handling: | Avoid freeze/thaw cycles, aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
| Shipping: | Blue Ice |
| Short Term Storage: | +4°C |
| Long Term Storage: | -20°C |
| Scientific Background: | Polycomb 2 is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of proper expression patterns of developmental master regulators; changes in expression pf PcG proteins have been associated with cancer. Polycomb 2 is a part of the cellular memory system responsible for the inheritance of gene activity by progeny cells. It participates in maintaining the transcriptionally repressive state of genes. Polycomb 2 is part of acomplex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Polycomb 2 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. |
| Regulatory Status: | RUO - Research Use Only |
