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PC2 polyclonal antibody

 
ENZ-ABS269-0100 100 µl 250.00 USD
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Product Specification

Alternative Name:Proprotein convertase 2, PCSK2, Neuroendocrine convertase 2
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 87-116 of N-terminal human PC2 conjugated to KLH.
 
UniProt ID:P16519
 
Species reactivity:Human, Mouse
 
Crossreactivity:Predicted to react with pig and rat based on sequence homology.
 
Applications:Flow Cytometry, ICC, IF, IHC, WB
 
Recommended Dilutions/Conditions:Flow Cytometry (1:10-1:50)
Immunocytochemistry (1:10-1:50)
Immunofluorescence (1:10-1:50)
Immunohistochemistry (1:10-1:50)
Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Liquid. In PBS containing 0.09% sodium azide.
 
Use/Stability:May be stored at +4°C for up to 6 months.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:PC2 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This protein is a proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. The protein is also known to cleave proopiomelanocortin, proenkephalin, prodynorphin and proluteinizing-hormone-releasing hormone.
 
ENZ-ABS269 Flow
Flow cytometry analysis of K562 cells using a PC2, pAb (Prod. no ENZ-ABS269 (right) compared to a negative control cell (left) at a dilution of 1:10-50, followed by a FITC-conjugated goat anti-rabbit antibody.
ENZ-ABS269 IF
Immunofluorescent analysis of 293 cells using a PC2, pAb (Prod no. ENZ-ABS269) at a dilution of 1:10-50, followed by a fluor-conjugated goat anti-rabbit secondary antibody (green). Nuclei were stained with DAPI (blue).
ENZ-ABS269 IHC
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human brain tissue using a PC2, pAb (Prod no. ENZ-ABS269), followed by HRP-conjugated secondary antibody and DAB staining.
ENZ-ABS269 WB
Western blot analysis using a PC2, pAb (Prod. no ENZ-ABS269) in mouse cerebellum tissue lysates (35ug per lane).
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ENZ-ABS269 Flow ENZ-ABS269 IF ENZ-ABS269 IHC ENZ-ABS269 WB

General Literature References

Attenuation of the polypeptide 7B2, prohormone convertase PC2, and vasopressin in the hypothalamus of some Prader-Willi patients: indications for a processing defect: B.A. Gabreels, et al.; J. Clin. Endocrinol. Metab. 83, 591 (1998), Abstract;

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