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PC2 polyclonal antibody

 
ENZ-ABS269-0100 100 µl 263.00 USD
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Product Specification

Alternative Name:Proprotein convertase 2, PCSK2, Neuroendocrine convertase 2
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 87-116 of N-terminal human PC2 conjugated to KLH.
 
UniProt ID:P16519
 
Species reactivity:Human, Mouse
 
Crossreactivity:Predicted to react with pig and rat based on sequence homology.
 
Applications:Flow Cytometry, ICC, IF, IHC, WB
 
Recommended Dilutions/Conditions:Flow Cytometry (1:10-1:50)
Immunocytochemistry (1:10-1:50)
Immunofluorescence (1:10-1:50)
Immunohistochemistry (1:10-1:50)
Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Liquid. In PBS containing 0.09% sodium azide.
 
Use/Stability:May be stored at +4°C for up to 6 months.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:PC2 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This protein is a proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. The protein is also known to cleave proopiomelanocortin, proenkephalin, prodynorphin and proluteinizing-hormone-releasing hormone.
 
PC2 polyclonal antibody Western blot
Western blot analysis using a PC2, pAb (Prod. no ENZ-ABS269) in mouse cerebellum tissue lysates (35ug per lane).
PC2 polyclonal antibody Immunohistochemistry
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human brain tissue using a PC2, pAb (Prod no. ENZ-ABS269), followed by HRP-conjugated secondary antibody and DAB staining.
PC2 polyclonal antibody Immunofluorescence
Immunofluorescent analysis of 293 cells using a PC2, pAb (Prod no. ENZ-ABS269) at a dilution of 1:10-50, followed by a fluor-conjugated goat anti-rabbit secondary antibody (green). Nuclei were stained with DAPI (blue).
PC2 polyclonal antibody Flow Cytometry
Flow cytometry analysis of K562 cells using a PC2, pAb (Prod. no ENZ-ABS269 (right) compared to a negative control cell (left) at a dilution of 1:10-50, followed by a FITC-conjugated goat anti-rabbit antibody.
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PC2 polyclonal antibody Western blot PC2 polyclonal antibody Immunohistochemistry PC2 polyclonal antibody Immunofluorescence PC2 polyclonal antibody Flow Cytometry

General Literature References

Attenuation of the polypeptide 7B2, prohormone convertase PC2, and vasopressin in the hypothalamus of some Prader-Willi patients: indications for a processing defect: B.A. Gabreels, et al.; J. Clin. Endocrinol. Metab. 83, 591 (1998), Abstract;

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