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RGMC (human) monoclonal antibody (1D7)

 
ENZ-ABS258-0100 100 µg 343.00 USD
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Product Specification

Alternative Name:Repulsive guidance molecule C, Hemojuvelin, Hemochromatosis type 2 protein, HFE2, HJV
 
Clone:1D7
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human RGMC (aa 36-398) (Prod. No. ALX-522-104).
 
UniProt ID:Q6ZVN8
 
Species reactivity:Human
 
Applications:ELISA, Flow Cytometry, IP, WB
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:The RGMC (also called Hemojuvelin) is a GPI-anchored protein involved in iron metabolism through regulation of hepcidin expression. Mutations in the gene encoding RGMC cause severe iron overload (juvenile hemochromatosis /hemochromatosis type 2A). The protein binds to neogenin and acts as co-receptor of the bone morphogenetic protein. The mature RGMc protein is proteolytically processed and glycosylated.
 
RGMC (human) monoclonal antibody (1D7) Flow Cytometry
Flow cytometry analysis of HEK293 cells stably overexpressing RGMC stained with RGMC (human), mAb (1D7) [Prod no. ENZ-ABS258] at 1:100 dilution (blue line) or normal mouse IgG (control, purple line).
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RGMC (human) monoclonal antibody (1D7) Flow Cytometry

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