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RGMC (human) monoclonal antibody (1D7)

 
ENZ-ABS258-0100 100 µg 326.00 USD
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Product Specification

Alternative Name:Repulsive guidance molecule C, Hemojuvelin, Hemochromatosis type 2 protein, HFE2, HJV
 
Clone:1D7
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human RGMC (aa 36-398) (Prod. No. ALX-522-104).
 
UniProt ID:Q6ZVN8
 
Species reactivity:Human
 
Applications:ELISA, Flow Cytometry, IP, WB
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:The RGMC (also called Hemojuvelin) is a GPI-anchored protein involved in iron metabolism through regulation of hepcidin expression. Mutations in the gene encoding RGMC cause severe iron overload (juvenile hemochromatosis /hemochromatosis type 2A). The protein binds to neogenin and acts as co-receptor of the bone morphogenetic protein. The mature RGMc protein is proteolytically processed and glycosylated.
 
ENZ-ABS258 flow
Flow cytometry analysis of HEK293 cells stably overexpressing RGMC stained with RGMC (human), mAb (1D7) [Prod no. ENZ-ABS258] at 1:100 dilution (blue line) or normal mouse IgG (control, purple line).
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ENZ-ABS258 flow

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