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CARMA1 polyclonal antibody

 
ENZ-ABS101-0100 100 µl 441.00 USD
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Product Specification

Alternative Name:CARD11, Bimp3, Caspase recruitment domain-containing protein 11, CARD-containing MAGUK protein 1
 
Host:Rabbit
 
Immunogen:Recombinant fragment corresponding to a region within amino acids 25 and 275 of human CARMA1.
 
UniProt ID:Q9BXL7
 
Species reactivity:Human, Mouse
 
Applications:IHC (PS), WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections, 1:100-1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Positive Control:For Positive Control (Western blot) see Prod. No. ALX-840-606.
 
Formulation:Liquid. In 0.1M TRIS, pH 7, containing 10% glycerol, 0.1M glycine, and 0.01% thimerosal.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

General Literature References

Interaction of calmodulin with Bcl10 modulates NF-kappaB activation: S. Edin, et al.; Mol. Immunol. 47, 2057 (2010), Application(s): Immunoblotting with cell lysates, Abstract;
MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity: M.E. Moreno-Garcia, et al.; Mol. Cell Biol. 30, 922 (2010), Application(s): Immunoblotting with cell lysates, Abstract; Full Text
T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b: G. Qiao, et al.; Mol. Cell Biol. 28, 2470 (2008), Application(s): Immunoblotting with immunoprecipitates, Abstract; Full Text
The proteolytic activity of the paracaspase MALT1 is key in T cell activation: F. Rebeaud, et al.; Nat. Immunol. 9, 272 (2008), Abstract;
Bcl10 controls TCR- and FcgammaR-induced actin polymerization: D. Rueda, et al.; J. Immunol. 178, 4373 (2007), Application(s): Immunoblotting with cell lysates, Abstract; Full Text
Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1: R.B. Medeiros, et al.; Science 316, 754 (2007), Abstract;
MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-kappa B-dependent proliferative advantage and resistance against FAS-induced cell death in B cells: L. Ho, et al.; Blood 105, 2891 (2005), Application(s): Immunoblotting with cell lysates, Abstract; Full Text
Overexpression of caspase recruitment domain (CARD) membrane-associated guanylate kinase 1 (CARMA1) and CARD9 in primary gastric B-cell lymphoma: S. Nakamura, et al.; Cancer 104, 1885 (2005), Application(s): Immunohistochemistry on FFPE tissue, Abstract; Full Text
A requirement for CARMA1 in TCR-induced NF-kappa B activation: D. Wang, et al.; Nat. Immunol. 3, 830 (2002), Abstract;
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappaB activation: O. Gaide, et al.; Nat. Immunol. 3, 836 (2002), Abstract;
Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation: O. Gaide, et al.; FEBS Lett. 496, 121 (2001), Abstract;

Related Products

Positive control (cell lysate), for antibodies to CARMA1 (human) 

Whole cell lysate of HEK 293T cells transfected with an expression plasmid for human CARMA1 (CARD-containing MAGUK protein 1) (aa 1-1147) fused at the C-terminus to a FLAG®-tag. | Print as PDF
 
ALX-840-606-R100 100 µl 48.00 USD
Do you need bulk/larger quantities?
 

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