Product Details
| Alternative Name: | CARD11, Bimp3, Caspase recruitment domain-containing protein 11, CARD-containing MAGUK protein 1 |
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| Host: | Rabbit |
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| Immunogen: | Recombinant fragment corresponding to a region within amino acids 25 and 275 of human CARMA1. |
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| UniProt ID: | Q9BXL7 |
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| Species reactivity: | Human, Mouse
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| Applications: | IHC (PS), WB
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| Recommended Dilutions/Conditions: | Immunohistochemistry (paraffin sections, 1:100-1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Formulation: | Liquid. In 0.1M TRIS, pH 7, containing 10% glycerol, 0.1M glycine, and 0.01% thimerosal. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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General Literature References
Interaction of calmodulin with Bcl10 modulates NF-kappaB activation: S. Edin, et al.; Mol. Immunol.
47, 2057 (2010),
Application(s): Immunoblotting with cell lysates,
Abstract;
MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity: M.E. Moreno-Garcia, et al.; Mol. Cell Biol.
30, 922 (2010),
Application(s): Immunoblotting with cell lysates,
Abstract;
Full Text
T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b: G. Qiao, et al.; Mol. Cell Biol.
28, 2470 (2008),
Application(s): Immunoblotting with immunoprecipitates,
Abstract;
Full Text
The proteolytic activity of the paracaspase MALT1 is key in T cell activation: F. Rebeaud, et al.; Nat. Immunol.
9, 272 (2008),
Abstract;
Bcl10 controls TCR- and FcgammaR-induced actin polymerization: D. Rueda, et al.; J. Immunol.
178, 4373 (2007),
Application(s): Immunoblotting with cell lysates,
Abstract;
Full Text
Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1: R.B. Medeiros, et al.; Science
316, 754 (2007),
Abstract;
MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-kappa B-dependent proliferative advantage and resistance against FAS-induced cell death in B cells: L. Ho, et al.; Blood
105, 2891 (2005),
Application(s): Immunoblotting with cell lysates,
Abstract;
Full Text
Overexpression of caspase recruitment domain (CARD) membrane-associated guanylate kinase 1 (CARMA1) and CARD9 in primary gastric B-cell lymphoma: S. Nakamura, et al.; Cancer
104, 1885 (2005),
Application(s): Immunohistochemistry on FFPE tissue,
Abstract;
Full Text
A requirement for CARMA1 in TCR-induced NF-kappa B activation: D. Wang, et al.; Nat. Immunol.
3, 830 (2002),
Abstract;
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappaB activation: O. Gaide, et al.; Nat. Immunol.
3, 836 (2002),
Abstract;
Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation: O. Gaide, et al.; FEBS Lett.
496, 121 (2001),
Abstract;
