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Wnt-3a (mouse), (recombinant)

Modulator of embryogenesis, cell proliferation, stem cell differentation, and bone, glucose and lipid metabolism
 
ENZ-60001-C001 1 µg 156.00 USD
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Product Specification

MW:~40kDa (SDS-PAGE)
 
Source:Produced in CHO cells
 
UniProt ID:P27467
 
Formulation:Lyophilized solid.
 
Purity:≥80% (SDS-PAGE)
 
Endotoxin Content:<1.0EU/µg (LAL method)
 
Biological Activity:Wnt-3a can induce β-catenin mediated response in a TCF/LEF reporter gene luciferase assay.
 
Reconstitution:Prepare 5 μg/mL stock solution of Wnt3a by adding 200 μL deionized water into the vial of lyophilized Wnt3a.
 
Shipping:Shipped on Dry Ice
 
Short Term Storage:-80°C
 
Long Term Storage:-80°C
 
Use/Stability:Stable for at least 12 months after receipt when stored, as supplied, at -80°C. Following reconstitution, stable for three months when stored at or below -20°C.
 
Scientific Background:Wnt expression and signal transduction have been identified as critical components in regulating embryogenesis, cell proliferation, and bone, glucose and lipid metabolism. Wnt-3a signalling also plays a role in regulating the differentation of stem cells. Wnt-3a is a member of the highly conserved, structurally related cysteine-rich Wnt family glycoproteins important for normal developmental processes and oncogenesis. Wnt-3a proteins are secreted and bind to receptors of the Frizzled and LRP families on the cell surface, which leads to the stabilization of β-catenin and increase of β-catenin translocation into the nucleus where it binds to TCF/LEF transcription factors to promote gene expression. The predicted mouse Wnt-3a protein of 352 amino acid residues and contains an N-terminal signal peptide for secretion. It shares 96% amino acid identity to human Wnt-3a protein. Due to glycosylation, it migrates at an apparent molecular weight of ~40 kDa by SDS-PAGE analysis under reducing conditions. 
 
Technical Info/Product Notes:Application Note:
New LEADING LIGHT Wnt Reporter Assay with Highest Sensitivity in Response to Wnt Effectors
 

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