Congo Red, has been used in microscopy for staining elastic fibers and bacteria. Amyloid protein, an abnormal protein aggregate associated with various pathologies, is commonly detected in tissue with Congo Red. Detection of amyloid is relevant for a whole host of diseases, including Alzheimer’s disease, Creutzfeld-Jakob’s disease and Bovine Spongiform Encephalopathy. The birefringence of Congo Red-stained amyloid, appearing green under polarized light, improves detection relative to simple visible examination of the colored deposits. Additionally, upon binding to amyloid, Congo Red displays bright fluorescence emission at 614 nm. Wavelength Maxima: Excitation 497nm
Product Details
| Formula: | C32H22N6Na2O6S2 |
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| MW: | 696.7 |
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| CAS: | 573-58-0 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Dark brown-red solid. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least one year after receipt when stored as recommended. |
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| Handling: | Protect from light. Keep cool and dry. |
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| Technical Info/Product Notes: | This product is a member of the CELLESTIAL® product line, reagents and assay kits comprising fluorescent molecular probes that have been extensively benchmarked for live cell analysis applications. CELLESTIAL® reagents and kits are optimal for use in demanding imaging applications, such as confocal microscopy, flow cytometry and HCS, where consistency and reproducibility are required. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Physical basis of colors seen in Congo red-stained amyloid in polarized light: A.J. Howie, et al.; Lab. Invest.
88, 232 (2008),
Abstract;
Quantification of cerebral amyloid angiopathy and parenchymal amyloid plaques with Congo red histochemical stain: D.M. Wilcock, et al.; Nat. Protoc.
1, 1591 (2006),
Abstract;
