Product Details
| Alternative Name: | Neuroendocrine, CgA |
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| Clone: | PHE5 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Human pheochromocytoma. |
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| UniProt ID: | P10645 |
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| Source: | Purified from hybridoma tissue culture supernatant. |
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| Species reactivity: | Human
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| Specificity: | PHE5 is specific to chromogranin A, a highly acidic protein associated with the “dense core” granules of many cells of the neural and neuroendocrine system. It reacts with neuroendocrine cells of the gut, pancreatic islet and adrenal medulla, but does not react with any cells in the brain or with melanoma cells. The antibody stains carcinoid tumors, pheochromocytomas and paragangliomas. It is nonreactive with carcinomas, lymphomas and sarcomas. |
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| Applications: | IHC (PS)
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| Recommended Dilutions/Conditions: | Immunohistochemistry (paraffin sections; this antibody can be used for staining of paraffin-embedded tissue sections fixed in neutral buffered formalin and is compatible with most commonly used histological fixatives. Choose a good quality enzyme-linked anti-mouse IgG1 antibody for detection). Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually. |
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| Purity Detail: | Affinity purified. |
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| Formulation: | Liquid. Ready-to-use solution in PBS containing 0.1% sodium azide and 1% BSA. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Immunohistochemistry analysis of human endocrine pancreas tissue stained with chromogranin A, mAb (PHE5). Original magnifications: 5x and 63x, respectively.
Immunohistochemistry analysis of human endocrine pancreas tissue stained with chromogranin A, mAb (PHE5). Original magnifications: 5x and 63x, respectively.
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Product Literature References
Comparative study of seven neuroendocrine markers in pancreatic endocrine tumours: C. Bordi, et al.; Virchows Arch. A. Pathol. Anat. Histopathol.
413, 387 (1988),
Abstract;
Distribution of chromogranin A and secretogranin I (chromogranin B) in neuroendocrine cells and tumors: R.V. Lloyd, et al.; Am. J. Pathol.
130, 296 (1988),
Abstract;
Full Text
PHE5, a new monoclonal antibody to a unique neuroendocrine granule protein: K. Riddell, et al.; Lab. Invest. 56, 64A (1987),
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