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MBL oligomer ELISA kit

 
BPD-KIT-029 96 wells 741.00 USD
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  • Highly sensitive measurement, detecting as low of 2 ng/ml of oligomerized MBL
  • High throughput format with results in just 4 hours for up to 40 samples in duplicate
  • Ready-to-use pre-coated plate and individual calibrators saves time and reduce errors
  • Fully quantitative results that surpass semi-quantitative Western blot analysis
An immunometric ELISA for the measurement of oligomerized MBL in human samples. Absorbance is read at 450nm. Mannan-binding lectin (MBL) is an important component of the innate immune system. In at least 12% of the average Caucasian population, the circulating level of functional MBL is insufficient. This makes MBL deficiency by far the most common primary immunodeficiency.
BPD-KIT-029 std curve
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BPD-KIT-029 std curve

Product Specification

Alternative Name:Mannan-binding lectin, Mannose binding lectin
 
Sensitivity:2ng/ml (range 0.50-40ng/ml)
 
Assay Time:<4 hours
 
Applications:ELISA, Colorimetric detection
 
Application Notes:For the quantitative determination of oligomerized MBL in human serum and plasma.
 
Species reactivity:Human
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Kit/Set Contains:1: 12 strips of 8 Microwells each coated with anti-MBL antibody (96 wells) + frame 2: Sample Diluent 3: MBL Calibrators 1-8; 0, 0.5, 1, 2, 5, 10, 20, 40 ng/mL 4: 25X Wash Solution Concentrate 5: Biotinylated MBL Antibody 6: HRP-Streptavidin Conjugate 7: TMB Substrate 8: Stop Solution
 
Scientific Background:MBL (Mannan-Binding Lectin) is a carbohydrate-binding protein produced in the liver and secreted into the blood. The protein plays a key factor in innate immunity, functioning as a player in the complement activation cascade and defending the body against invading microorganisms (bacteria, viruses, protozoa and fungi).
 
Technical Info/Product Notes:Please click here for the original manufacturer datasheet.
 
UniProt ID:P11226
 
Manufacturer:Manufactured by BioPorto Diagnostics.
 

Product Literature References

A study on anti-mannose binding lectin (anti-MBL) antibodies and serum MBL levels in Indian systemic lupus erythematosus patients: V. Pradhan, et al.; Rheumatol. Int. 33, 1193 (2013), Application(s): ELISA using human serum, Abstract;
Biomarkers in the assessment of acute and chronic kidney diseases in the dog and cat: A.R. Cobrin, et al.; J. Small. Anim. Pract. 54, 647 (2013), Abstract;
Characterization of mannose-binding lectin (MBL) variants by allele-specific sequencing of MBL2 and determination of serum MBL protein levels: M. Adamek, et al.; Tissue Antigens 82, 410 (2013), Application(s): ELISA using human serum, Abstract;
Correlation between complement component levels and disease severity in dengue patients in Indonesia: A. Yamanaka, et al.; Jpn. J. Infect. Dis. 66, 366 (2013), Abstract;
Correlation between Complement Component Levels and Disease Severity in Dengue Patients in Indonesia.: A. Yamanaka, et al.; Jpn. J. Infect. Dis. 66, 366 (2013), Application(s): ELISA using human serum, Abstract; Full Text
Increased risk of pertussis in adult patients with mannose-binding lectin deficiency: K. Gröndahl-Yli-Hannuksela, et al.; APMIS 121, 311 (2013), Application(s): ELISA using human serum, Abstract;
Increased titers of anti-Saccharomyces cerevisiae antibodies in Crohn's disease patients with reduced H-ficolin levels but normal MASP-2 activity: T. Schaffer, et al.; J. Crohns Colitis 7, e1 (2013), Abstract;
Low mannose-binding lectin (MBL) is associated with paediatric inflammatory bowel diseases and ileal involvement in patients with Crohn disease: M. Kovacs, et al.; J. Crohns Colitis 7, 134 (2013), Abstract;
Aspergillus bronchitis without significant immunocompromise: A. Chrdle, et al.; Ann. N. Y. Acad. Sci. 1272, 73 (2012), Abstract;
Complement defects in patients with chronic rhinosinusitis: M.Q. Gaunsbaek, et al.; PLoS One 7, e47383 (2012), Abstract;
Elevated levels of vitamin D and deficiency of mannose binding lectin in dengue hemorrhagic fever: K. Alagarasu, et al.; Virol. J. 9, 86 (2012), Abstract;
Functional mannose-binding lectin levels in patients with end-stage renal disease on maintenance hemodialysis: A. Satomura, et al.; J. Innate. Immun. 4, 293 (2012), Abstract;
Impact of mannose-binding lectin deficiency on radiocontrast-induced renal dysfunction: a post-hoc analysis of a multicenter randomized controlled trial: M. Osthoff, et al.; BMC Nephrol. 13, 99 (2012), Abstract;
Mannose-binding lectin 2 polymorphisms do not influence frequency or type of infection in adults with chemotherapy induced neutropaenia: M. Wong, et al.; PLoS One 7, e30819 (2012), Abstract;
Mannose-binding lectin genotype and serum levels in patients with chronic and allergic pulmonary aspergillosis: E. Harrison, et al.; Int. J. Immunogenet. 39, 224 (2012), Abstract;
MBL interferes with endovascular trophoblast invasion in pre-eclampsia: C. Agostinis, et al.; Clin. Dev. Immunol. 2012, 484321 (2012), Abstract;
Plasma mannose-binding lectin is stimulated by PPARα in humans: M. Rakhshandehroo, et al.; Am. J. Physiol. Endocrinol. Metab. 302, E595 (2012), Abstract;
Pulmonary innate immunity in children with protracted bacterial bronchitis: A.B. Chang, et al.; J. Pediatr. 161, 621 (2012), Abstract;
Serum killing of Ureaplasma parvum shows serovar-determined susceptibility for normal individuals and common variable immuno-deficiency patients: M.L. Beeton, et al.; Immunobiology 217, 187 (2012), Abstract;
Complement-mediated neutralization of dengue virus requires mannose-binding lectin: P. Avirutnan, et al.; MBio. 2, e00276-11 (2011), Abstract;
Enhanced activity of meprin-О±, a pro-migratory and pro-angiogenic protease, in colorectal cancer: D. Lottaz, et al.; PLoS One 6, e26450 (2011), Abstract;
Mannan-binding lectin (MBL) and MBL-associated serine protease-2 in children with cancer: U.P. Fisch, et al.; Swiss Med. Wkly. 141, w13191 (2011), Abstract;
Mannose-binding lectin deficiency is associated with smaller infarction size and favorable outcome in ischemic stroke patients: M. Osthoff, et al.; PLoS One 6, e21338 (2011), Abstract;
Novel assays to assess the functional capacity of the classical, the alternative and the lectin pathways of the complement system: Y. Palarasah, et al.; Clin. Exp. Immunol. 164, 388 (2011), Abstract;
Serum concentration of complement components of the lectin pathway in maintenance hemodialysis patients, and relatively higher levels of L-Ficolin and MASP-2 in Mannose-binding lectin deficiency: M. Ishii, et al.; Ther. Apher. Dial. 15, 441 (2011), Abstract;
Serum concentrations of lectin-pathway components in healthy neonates, children and adults: mannan-binding lectin (MBL), M-, L-, and H-ficolin, and MBL-associated serine protease-2 (MASP-2): S. Sallenbach, et al.; Pediatr. Allergy Immunol. 22, 424 (2011), Abstract;
Systemic lupus erythematosus as a first presentation of common variable immunodeficiency associated with infrequent mannose-binding lectin gene polymorphisms: M. Torres-Salido, et al.; Rheumatol. Int. 31, 537 (2011), Abstract;
Differential role of the lectin pathway of complement activation in susceptibility to neonatal sepsis: L.J. Schlapbach, et al.; Clin. Infect. Dis. 51, 153 (2010), Abstract;
Endothelial response to childhood infection: the role of mannose-binding lectin (MBL): M. Charakida, et al.; Atherosclerosis 208, 217 (2010), Abstract;
Influence of functional deficiency of complement mannose-binding lectin on outcome of patients with acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: M. Trendelenburg, et al.; Eur. Heart J. 31, 1181 (2010), Abstract;
Influence of mannose-binding lectin genotypes and serostatus in allo-SCT: analysis of 131 recipients and donors: O.W. Neth, et al.; Bone Marrow Transplant. 45, 13 (2010), Abstract;
Mannose Binding Lectin Serum Level and Gene Polymorphism in Patients with SLE and its Relation to the Development of Lupus Nephritis: K. Okasha, et al.; Nephro-Urol. Mon. 2, 401 (2010), Full Text
Mannose-binding lectin is produced by vaginal epithelial cells and its level in the vaginal fluid is influenced by progesterone: R. Bulla, et al.; Mol. Immunol. 48, 281 (2010), Abstract;
Mannose-binding lectin levels and major infections in a cohort of very long-term survivors after allogeneic stem cell transplantation: M. Osthoff, et al.; Haematologica 95, 1389 (2010), Abstract;
MBL2 polymorphism and autoimmune markers: reconsidering the complexity of biological systems in the choice of controls: F.M. de Melo, et al.; Int. J. Immunogen. 38, 105 (2010), Abstract;
Mannose-binding lectin polymorphisms and recurrent respiratory tract infection in Chinese children: J. Chen, et al.; Eur. J. Pediatr. 168, 1305 (2009), Abstract;
Baseline mannose binding lectin levels may not predict infection among children with leukemia: J.E. Rubnitz, et al.; Pediatr. Blood Cancer 50, 866 (2008), Abstract;
Detrimental effects of mannose-binding lectin (MBL2) promoter genotype XA/XA on HIV-1 vertical transmission and AIDS progression: A. Mangano, et al.; J. Infect. Dis. 198, 694 (2008), Abstract;
Effect of pericardial blood processing on postoperative inflammation and the complement pathways: B. Marcheix, et al.; Ann. Thorac. Surg. 85, 530 (2008), Abstract;
High-producing MBL2 genotypes increase the risk of acute and chronic carditis in patients with history of rheumatic fever: M.D. Schafranski, et al.; Mol. Immunol. 45, 3827 (2008), Abstract;
Higher cord blood levels of mannose-binding lectin-associated serine protease-2 in infants with necrotising enterocolitis: L.J. Schlapbach, et al.; Pediatr. Res. 64, 562 (2008), Abstract;
Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults: M.I. Garcia-Laorden, et al.; J. Allergy Clin. Immunol. 122, 368--74, 374.e1-2 (2008), Abstract;
MBL2 genetic screening in patients with recurrent vaginal infections: M. Milanese, et al.; Am. J. Reprod. Immunol. 59, 146 (2008), Abstract;
Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women: M. Manco, et al.; J. Clin. Endocrinol. Metab. 92, 483 (2007), Abstract;
Hypercomplementemia in adult patients with IgA nephropathy: K. Onda, et al.; J. Clin. Lab. Anal. 21, 77 (2007), Abstract;
Low serum levels of mannose binding lectin are a risk factor for neonatal sepsis: F. de Benedetti, et al.; Pediatr. Res. 61, 325 (2007), Abstract;
Mannan-binding lectin (MBL) in women with tumours of the reproductive system: A.S. Swierzko, et al.; Cancer Immunol. Immunother. 56, 959 (2007), Abstract;
Mannose binding lectin gene variants and susceptibility to tuberculosis in HIV-1 infected patients of South India: K. Alagarasu, et al.; Tuberculosis (Edinb.) 87, 535 (2007), Abstract;
Mannose binding lectin levels in spondyloarthropathies: S.Z. Aydin, et al.; J. Rheumatol. 34, 2075 (2007), Abstract;
Serum levels of mannose-binding lectin and the risk of fever in neutropenia pediatric cancer patients: L.J. Schlapbach, et al.; Pediatr. Blood Cancer 49, 11 (2007), Abstract;
Autoimmune pancreatitis and complement activation system: T. Muraki, et al.; Pancreas 32, 16 (2006), Abstract;
Endotoxin immunity and the development of the systemic inflammatory response syndrome in critically ill children: R.C. M. Stephens, et al.; Intensive Care Med. 32, 286 (2006), Abstract;
Influence of mannose-binding lectin on HIV infection and tuberculosis in a Western-European population: M.I. Garcia-Laorden, et al.; Mol. Immunol. 43, 2143 (2006), Abstract;
Low clinical penetrance of mannose-binding lectin-associated serine protease 2 deficiency: M.I. Garcia-Laorden, et al.; J. Allergy Clin. Immunol. 118, 1383 (2006), Abstract;
Mannose-binding lectin and vulvovaginal candidiasis: F. Liu, et al.; Int. J. Gynaecol. Obstet. 92, 43 (2006), Abstract;
Mannose-binding lectin does not act as an acute-phase reactant in adults with community-acquired pneumococcal pneumonia: M. Perez-Castellano, et al.; Clin. Exp. Immunol. 145, 228 (2006), Abstract;
Mannose-binding lectin in susceptibility and progression of HIV-1 infection in children: A. Dzwonek, et al.; Antivir. Ther. 11, 499 (2006), Abstract;
Protection from inflammatory disease in insulin resistance: the role of mannan-binding lectin: J.M. Fernández-Real, et al.; Diabetologia 49, 2402 (2006), Abstract;
Quantification of mannan-binding lectin: P.D. Frederiksen, et al.; J. Immunol. Methods 315, 49 (2006), Abstract;
Role of mannose binding lectin gene variants on its protein levels and macrophage phagocytosis with live Mycobacterium tuberculosis in pulmonary tuberculosis: P. Selvaraj, et al.; FEMS Immunol. Med. Microbiol. 46, 433 (2006), Abstract;
The association between mannose-binding lectin gene polymorphism and rheumatic heart disease: I.J. Messias Reason, et al.; Hum. Immunol. 67, 991 (2006), Abstract;
Analysis of mannose-binding lectin 2 (MBL2) genotype and the serum protein levels in the Korean population: S.G. Lee, et al.; Mol. Immunol. 42, 969 (2005), Abstract;
Common variable immunodeficiency and the complement system; low mannose-binding lectin levels are associated with bronchiectasis: B. Fevang, et al.; Clin. Exp. Immunol. 142, 576 (2005), Abstract;
Immunogenetic polymorphism in Guillain-Barré syndrome: C.P.W. Geleijns; (2005), (dissertation), Full Text
Mannan-binding lectin and procalcitonin measurement for prediction of postoperative infection: M. Siassi, et al.; Crit. Care 9, R483 (2005), Abstract;
Mannose binding lectin and C3 act as recognition molecules for infectious agents in the vagina: V. Pellis, et al.; Clin. Exp. Immunol. 139, 120 (2005), Abstract;
Modulatory effect of mannose-binding lectin on cytokine responses: possible roles in HIV infection: L. Heggelund, et al.; Eur. J. Clin. Invest. 35, 765 (2005), Abstract;
Serum mannose-binding lectin levels are decreased in behcet's disease and associated with disease severity: N. Inanc, et al.; J. Rheumatol. 32, 287 (2005), Abstract;
Altered distribution of mannose-binding lectin alleles at exon I codon 54 in women with vulvar vestibulitis syndrome: O. Babula, et al.; Am. J. Obstet. Gynecol. 191, 762 (2004), Abstract;
Chronic mucocutaneous candidiasis and primary hypothyroidism in two families: A.G. Myhre, et al.; Eur. J. Pediatr. 163, 604 (2004), Abstract;
Genetic variants of the mannan-binding lectin are associated with immune reactivity to mannans in Crohn's disease: F. Seibold, et al.; Gastroenterology 127, 1076 (2004), Abstract;
Impaired pulmonary status in cystic fibrosis adults with two mutated MBL-2 alleles: J.C. Davies, et al.; Eur. Respir. J. 24, 798 (2004), Abstract;
Mannose-binding lectin gene polymorphisms are associated with gestational diabetes mellitus: A. Megia, et al.; J. Clin. Endocrinol. Metab. 89, 5081 (2004), Abstract;
Significantly increased levels of mannose-binding lectin (MBL) in rheumatic heart disease: a beneficial role for MBL deficiency: M.D. Schafranski, et al.; Clin. Exp. Immunol. 138, 521 (2004), Abstract;
Assays for human mannose-binding lectin: M.W. Turner, et al.; J. Immunol. Methods 276, 147 (2003), Abstract;
Low levels of mannose-binding lectin do not affect occurrence of severe infections or duration of fever in acute myeloid leukaemia during remission induction therapy: O.J. Bergmann, et al.; Eur. J. Haematol. 70, 91 (2003), Abstract;
Mannan-binding lectin in children with Escherichia coli O157:H7 haemmorrhagic colitis and haemolytic uraemic syndrome: F. Proulx, et al.; Clin. Exp. Immunol. 133, 360 (2003), Abstract;
Mannose-binding lectin in HIV infection: relation to disease progression and highly active antiretroviral therapy: L. Heggelund, et al.; J. Acquir. Immune Defic. Syndr. 32, 354 (2003), Abstract;
Mannose-binding lectin: comparison of two assays for the quantification of MBL in the serum of pediatric patients: E. Förster-Waldl, et al.; J. Immunol. Methods 276, 143 (2003), Abstract;
Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus: O. Neth, et al.; J. Immunol. 169, 4430 (2002), Abstract;
Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a prospective study: O. Neth, et al.; Lancet 358, 614 (2001), Abstract;
Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers: R. Steffensen, et al.; J. Immunol. Methods 241, 33 (2000), Application(s): ELISA using human plasma, Abstract;

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