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GLP-1 (7-36, amide) monoclonal antibody (4F3)

BPD-HYB-147-12-02 200 µg 645.00 USD
BPD-HYB-147-12-1 1 mg 2,891.00 USD
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Product Specification

Alternative Name:Glucagon like peptide 1
Immunogen:Synthetic peptide corresponding to aa 7-36 amide of GLP-1 coupled to carrier.
UniProt ID:P01275
Species reactivity:Mammalian
Applications:ELISA, IHC, WB
Purity Detail:Protein A/G-affinity purified.
Formulation:Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide.
Shipping:Blue Ice Not Frozen
Short Term Storage:+4°C
Scientific Background:Glucagon-like peptide 1(7-36)amide (GLP-1(7-36)amide) is the principal active form of GLP-1, the other being GLP-1(7-37). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.
Glucagon-like peptide-1 web
Figure: Schematic glucagon-like peptide-1 (GLP-1) showing active, extended and metabolite forms along with select GLP-1 monoclonal antibodies.
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Glucagon-like peptide-1 web

Product Literature References

Identification of serum proteins involved in pancreatic cancer cachexia: K. Felix, et al.; Life Sci. 88, 218 (2011), Application(s): Immunoaffinity SELDI-TOF MS of human serum samples, Abstract;
Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell: A.J. Mulherin, et al.; Endocrinology 152, 4610 (2011), Application(s): Radioimmunoassays with murine GLUTag, human NCI-H716 and rat FRIC cell lysates, Abstract; Full Text

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