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GLP-1 (7-36, amide) monoclonal antibody (8G9)

 
BPD-HYB-147-06-02 200 µg 632.00 USD
 
BPD-HYB-147-06-1 1 mg 2,834.00 USD
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Product Specification

Alternative Name:Glucagon like peptide 1
 
Clone:8G9
 
Host:Mouse
 
Isotype:IgG1κ
 
Immunogen:Synthetic peptide corresponding to aa 7-36 amide of GLP-1 coupled to carrier.
 
UniProt ID:P01275
 
Species reactivity:Mammalian
 
Applications:ELISA, IHC
 
Recommended Dilutions/Conditions:Immunohistochemistry (1:500)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein A/G-affinity purified.
 
Formulation:Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Short Term Storage:+4°C
 
Scientific Background:Glucagon-like peptide 1(7-36)amide (GLP-1(7-36)amide) is the principal active form of GLP-1, the other being GLP-1(7-37). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.
 
Glucagon-like peptide-1 web
Figure: Schematic glucagon-like peptide-1 (GLP-1) showing active, extended and metabolite forms along with select GLP-1 monoclonal antibodies.
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Glucagon-like peptide-1 web

Product Literature References

Elevated plasma GLP-1 levels and enhanced expression of cardiac GLP-1 receptors as markers of left ventricular systolic dysfunction: a cross-sectional study: A. Hattori, et al.; BMJ Open 3, e003201 (2013), Application(s): IHC using human endomyocardial biopsy samples, Abstract; Full Text
Exocrine and Endocrine Modulation in Common Gastric Carcinoma: V. Canzonieri, et al.; Am. J. Clin. Pathol. 137, 712 (2012), Application(s): IHC using human primary stomach cancers, Abstract; Full Text
Expression of connective tissue growth factor and IGF1 in normal and neoplastic gastrointestinal neuroendocrine cells and their clinico-pathological significance: G.A. Kaltsas, et al.; Endocr. Relat. Cancer 18, 61 (2011), Application(s): IHC using human ileal mucosa, Abstract; Full Text

General Literature References

Immunoblockade of endogenous glucagon-like peptide-1 by monoclonal antibodies in conscious rats: effect on the insulin response to intragastric glucose: J. van Delft, et al.; Metabolism 48, 41 (1999), Abstract;
Monoclonal antibodies to glucagone-like peptide-1: M. Ghiglione, et al.; Digestion 54, 396 (1993),

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