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Complement component C5b-9 (human) monoclonal antibody (aE11)

 
BPD-DIA-011-01-02 200 µg 571.00 USD
 
BPD-DIA-011-01-1 1 mg 2,591.00 USD
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Product Specification

Alternative Name:Terminal complement complex, TCC
 
Clone:aE11
 
Host:Mouse
 
Isotype:IgG2aκ
 
Immunogen:Purified human complement component C5b-9.
 
UniProt ID:P01031
 
Species reactivity:Human
 
Applications:ELISA, IF, IHC
 
Purity Detail:Protein A-affinity purified.
 
Formulation:Liquid. In 10mM phosphate buffer, pH 7.4, containing 0.15M sodium chloride and 0.09% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Short Term Storage:+4°C
 
Scientific Background:C5b-9, also known as the terminal complement complex (TCC), consists of C5b, C6, C7, C8 and C9, and it forms the membrane attack complex (MAC) as well as the non-lytic fluid-phase SC5b-9 complex (with protein S). The MAC forms channels in target cell membranes leading to cell lysis by osmotic leakage. The complexes contain neoantigens absent from the individual native components from which they are formed, and the antibody is directed against a neoepitope exposed on C9 when incorporated into the TCC.
 
BPD-DIA-011-01 IHC
IHC staining of frozen tonsil section. Vascular endothelia and dendritic cells of germinal center have strong and intensive label. Dilution: 1:10.
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BPD-DIA-011-01 IHC

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