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Ghrelin (human) monoclonal antibody (45)

 
BPD-ABS-050-45-02 200 µg 632.00 USD
 
BPD-ABS-050-45-1 1 mg 2,834.00 USD
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Product Specification

Clone:45
 
Host:Mouse
 
Isotype:IgG1λ
 
Immunogen:Synthetic peptide corresponding to the sequence of human human Ser3-octanoyl ghrelin-28
 
UniProt ID:Q9UBU3
 
Species reactivity:Human
 
Applications:ELISA, WB
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Ghrelin is an orexigenic (food intake stimulating) 27 or 28 amino-acid gut-brain peptide hormone produced by endocrine cells in the stomach, pancreatic islets and certain hypothalamic neurons. Two forms are produced by alternative mRNA splicing; Gln13 or 14 is missing from the second form. "Active" ghrelin is acylated (octanoylated) at Ser3; this form stimulates growth hormone secretion via GHS receptors and increases appetite. The des-acyl form does not have these effects but may have other actions. Plasma responses of total ghrelin to food may reflect those of active ghrelin.
 

General Literature References

Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates: K.E. Foster-Schubert, et al.; J. Clin. Endocrinol. Metab. 93, 1971 (2008), Abstract;
Ghrelin: structure and function: M. Kojima & K. Kangawa; Physiol. Rev. 85, 495 (2005), (Review), Abstract;
Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor: M. Kojima, et al.; Trends Endocrinol. Metab. 12, 118 (2001), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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