Product Details
| Clone: | 45 |
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| Host: | Mouse |
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| Isotype: | IgG1λ |
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| Immunogen: | Synthetic peptide corresponding to the sequence of human human Ser3-octanoyl ghrelin-28 |
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| UniProt ID: | Q9UBU3 |
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| Species reactivity: | Human
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| Applications: | ELISA, WB
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| Purity Detail: | Protein A affinity purified. |
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| Formulation: | Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide. |
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| Shipping: | Blue Ice Not Frozen |
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| Long Term Storage: | +4°C |
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| Scientific Background: | Ghrelin is an orexigenic (food intake stimulating) 27 or 28 amino-acid gut-brain peptide hormone produced by endocrine cells in the stomach, pancreatic islets and certain hypothalamic neurons. Two forms are produced by alternative mRNA splicing; Gln13 or 14 is missing from the second form. "Active" ghrelin is acylated (octanoylated) at Ser3; this form stimulates growth hormone secretion via GHS receptors and increases appetite. The des-acyl form does not have these effects but may have other actions. Plasma responses of total ghrelin to food may reflect those of active ghrelin. |
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| Regulatory Status: | RUO - Research Use Only |
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General Literature References
Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates: K.E. Foster-Schubert, et al.; J. Clin. Endocrinol. Metab.
93, 1971 (2008),
Abstract;
Ghrelin: structure and function: M. Kojima & K. Kangawa; Physiol. Rev.
85, 495 (2005), (Review),
Abstract;
Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor: M. Kojima, et al.; Trends Endocrinol. Metab.
12, 118 (2001),
Abstract;
