Product Details
Alternative Name: | Glucagon like peptide 1 |
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Clone: | 4 |
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Host: | Mouse |
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Isotype: | IgG1κ |
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Immunogen: | Synthetic peptide corresponding to aa 7-17 of GLP-1. |
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UniProt ID: | P01275 |
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Species reactivity: | Mammalian
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Crossreactivity: | Shows <0.2% cross-reactivity with GLP-1(1-37), GLP-1(9-36)amide, glucagon, human GIP and exendin-4. Cross-reacts approximately 1% with human GLP-2. |
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Applications: | ELISA, IHC
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Recommended Dilutions/Conditions: | Immunohistochemistry (1:500) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Not recommended for use in sandwich ELISA. |
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Purity Detail: | Protein A/G-affinity purified. |
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Formulation: | Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide. |
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Shipping: | Blue Ice Not Frozen |
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Short Term Storage: | +4°C |
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Scientific Background: | Glucagon-like peptide 1 (7-36) amide (GLP-1 (7-36) amide) is the principal active form of GLP-1, the other being GLP-1 (7-37). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far. |
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Regulatory Status: | RUO - Research Use Only |
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Figure: Schematic glucagon-like peptide-1 (GLP-1) showing active, extended and metabolite forms along with select GLP-1 monoclonal antibodies.
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Product Literature References
An ultrasensitive method for the quantitation of active and inactive GLP-1 in human plasma via immunoaffinity LC-MS/MS.: D. Chappell, et al.; Bioanalysis
6, 33 (2014),
Application(s): LC-MS/MS assay of human plasma samples,
Abstract;