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Z-Leu-Leu-Leu-vinyl sulfone

 
BML-ZW9170-0500 500 µg 291.00 USD
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Inhibits the trypsin-like, chymotrypsin-like and caspase-like (PGPH) activity in isolated proteasomes and living cells by covalent modification of the amino-terminal threonine of the catalytically active β subunits. The vinyl sulfone acts as a Michael acceptor for soft nucleophiles such as thiols, leading to the formation of a covalent bond, while being resistant to attack by free thiols, which can cause inactivation of other classes of protease inhibitors.

Product Specification

Sequence:Z-(Leu)3-vinyl sulfone
 
MW:~551.3 Da
 
Purity:≥99%
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
BML-ZW9170 structure
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BML-ZW9170 structure

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