Synergizers with Wnt3a to activate the Wnt/β-catenin pathway. Binds and inhibits GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1), thus activating ARF. It has also been suggested that a possible mechanism by which QS11 synergizes Wnt is through ARFGAP1 inhibition leading to increased β-catenin translocation via ARF activation.
Product Details
| Alternative Name: | (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-ylmethyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol |
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| Formula: | C35H33N5O2 |
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| MW: | 567.7 |
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| CAS: | 944328-88-5 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (25 mg/ml) or in 100% ethanol (25 mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. |
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| Handling: | Solutions can be stored at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Small-molecule synergist of the Wnt/ß-catenin signaling pathway: Q. Zhang et al.; Proc. Natl. Acad. Sci. USA
104, 7444 (2007),
Abstract;
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