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QS11

Wnt pathway activator
 
BML-WN117-0005 5 mg 132.00 USD
 
BML-WN117-0025 25 mg 553.00 USD
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Synergizers with Wnt3a to activate the Wnt/β-catenin pathway. Binds and inhibits GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1), thus activating ARF. It has also been suggested that a possible mechanism by which QS11 synergizes Wnt is through ARFGAP1 inhibition leading to increased β-catenin translocation via ARF activation.

Product Specification

Alternative Name:(2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-ylmethyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
 
Formula:C35H33N5O2
 
MW:567.7
 
CAS:944328-88-5
 
Purity:≥98% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (25 mg/ml) or in 100% ethanol (25 mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Solutions can be stored at -20°C for up to 3 months.
 
BML-Wn117 Structure
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BML-Wn117 Structure

Product Literature References

Small-molecule synergist of the Wnt/ß-catenin signaling pathway: Q. Zhang et al.; Proc. Natl. Acad. Sci. USA 104, 7444 (2007), Abstract; Full Text

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For Research Use Only. Not for use in diagnostic procedures.
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