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CCT036477

Disrupts Wnt signaling
 
BML-WN114-0005 5 mg 85.00 USD
 
BML-WN114-0025 25 mg 378.00 USD
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Inhibits Wnt signaling via blocking transcription at the β-catenin level independent of CBP or p300. Inhibited growth in several cancer cell lines (HT29, HCT116, SW480, and SNU475). CCT036447 was also active in vivo where it blocked development of zebrafish and Xenopus embryos and the expression of Wnt target genes.

Product Specification

Alternative Name:N-((4-Chlorophenyl)(2-methyl-1H-indol-3-yl)methyl)pyridin-2-amine
 
Formula:C21H18ClN3
 
MW:347.8
 
CAS:305372-78-5
 
Purity:≥98% (TLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C. Solutions can be stored at -20°C for up to 3 months.
 
Handling:Solutions can be stored at -20°C for up to 3 months.
 
BML-WN114 Structure
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BML-WN114 Structure

Product Literature References

A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription : K. Ewan et al. ; Cancer Res. 70, 5963 (2010), Abstract; Full Text

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