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BML-286

Disrupts Wnt signaling
 
BML-WN113-0010 10 mg 93.00 USD
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Cell-permeable compound that disrupts Wnt signaling by binding to the PDZ domain of dishevelled (Kd=10.6 µM). Blocked Wnt3a-induced transcription activity and was able to supress the Wnt pathway-dependent growth of prostate cancer PC-3 cells (IC50=12.5 µM). BML-286 was also capable of supressing Wnt signaling in vivo (Xenopus embryo and mouse hyaloids vessel system).

Product Specification

Alternative Name:3289-8625
 
Formula:C22H18N2O4
 
MW:374.4
 
CAS:294891-81-9
 
Purity:≥98% (HPLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C. Solutions can be stored at -20°C for up to 3 months.
 
Handling:Solutions can be stored at -20°C for up to 3 months.
 
BML-WN113 Structure
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BML-WN113 Structure

Product Literature References

Discovery and Characterization of a Small Molecule Inhibitor of the PDZ domain of Dishevelled: D. Grandy, et al.; J. Biol. Chem. 284, 16256 (2009), Abstract; Full Text

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Dishevelled
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Dishevelled Ligand
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