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FH535

Inhibits the recruitment of the co-activators β-catenin and GRIP1
 
BML-WN112-0005 5 mg 57.00 USD
 
BML-WN112-0025 25 mg 226.00 USD
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Antagonizes Wnt/β-catenin/Tcf-mediated transcription as well as PPARγ and δ activity. Able to inhibit the recruitment of the co-activators β-catenin and GRIP1, both of which are activators for both pathways. FH535 was toxic (LC50=5 to 15µM) to 10 of 12 carcinoma cell lines tested. A unique tool to study the relationship between Wnt and PPAR signaling pathways.

Product Specification

Alternative Name:N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonamide
 
Formula:C13H10Cl2N2O4S
 
MW:361.2
 
CAS:108409-83-2
 
Purity:≥98% (TLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (20mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C. Solutions can be stored at -20°C for up to 3 months.
 
Handling:Solutions can be stored at -20°C for up to 3 months.
 
BML-WN112 Structure
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BML-WN112 Structure

Product Literature References

Cell-based assay for low and high scale screening of the Wnt/β-catenin signaling modulators: M. Mazur, et al.; Anal. Biochem. 475, 56 (2015), Application(s): Cell Culture, Abstract;
A small-molecule inhibitor of Tcf/ß-catenin signaling down-regulates PPARτ and PPARδ activities : S. Handeli & J. Simon; Mol. Cancer Ther. 7, 521 (2008), Abstract; Full Text

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