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WAY-262611

DKK1 inhibitor
 
BML-WN110-0005 5 mg 115.00 USD
 
BML-WN110-0025 25 mg 458.00 USD
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Wnt pathway agonist acting via inhibition of Dkk1 with no GSK-3β inhibition. TCF-Luciferase EC50=0.63µM. WAY262611 was able to enhance trabecular bone formation rate in the tibia of OVX rats following oral administration.

Product Specification

Alternative Name:(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine
 
Formula:C20H22N4
 
MW:318.4
 
Purity:≥97% (TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (30mg/ml) or in 100% ethanol (25mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Solutions can be stored at -20°C for up to 3 months.
 
BML-WN110 Structure
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BML-WN110 Structure

Product Literature References

(1-(4-Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: A wingless b-Catenin Agonist That Increases Bone Formation Rate: J. Pelletier, et al.; J. Med. Chem. 52, 6962 (2009), Abstract;

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