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BML-284

Wnt activator
 
BML-WN105-0005 5 mg 116.00 USD
 
BML-WN105-0025 25 mg 460.00 USD
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Wnt agonist that activates Wnt signaling in cellular assays and a Xenopus model. Induces β-catenin and TCF-dependent transcriptional activity in a dose-dependent manner (EC50=0.7μM). Wnt activation occured in a GSK-3β independent manner.

Product Specification

Alternative Name:2-Amino-4-[3,4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl)pyrimidine
 
Formula:C19H18N4O3
 
MW:350.4
 
CAS:853220-52-7
 
Purity:≥98% (TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (25 mg/ml) or in 100% ethanol (25 mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Solutions can be stored at -20°C for up to 3 months.
 
BML-WN105 Structure
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BML-WN105 Structure

Product Literature References

A Small-Molecule Agonist of the Wnt Signaling Pathway: J. Liu, et al.; Angew. Chem. Int. Ed. 44, 1987 (2005), Abstract;

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