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PNU-74654

Catenin blocker
 
BML-WN101-0005 5 mg 80.00 USD
 
BML-WN101-0025 25 mg 344.00 USD
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Anti-tumor agent that disrupts the canonical Wnt/β-catenin pathway via blockage of the protein-protein interaction between β-catenin and TCF.

Product Specification

Alternative Name:2-Phenoxybenzoic acid [(5-methyl-2-furanyl)methylene]hydrazide
 
Formula:C19H16N2O3
 
MW:320.3
 
CAS:113906-27-7
 
Purity:≥98% (HPLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (25 mg/ml) and in 100% ethanol (8 mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Solutions can be stored at -20°C for up to 3 months.
 
BML-WN101 Structure
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BML-WN101 Structure

Product Literature References

Inhibition of protein-protein interactions: The discovery of druglike ß-catenin inhibitors by combining virtual and biophysical screening: J.-Y. Trosset, et al.; Proteins 64, 60 (2006), Abstract;
Mining the Wnt pathway for cancer therapeutics: N. Barker & H. Clevers; Nat. Rev. Drug Discov. 5, 997 (2006), Abstract;

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