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XAV939

PARP5a inhibitor
 
BML-WN100-0005 5 mg 56.00 USD
 
BML-WN100-0025 25 mg 215.00 USD
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Potent inhibitor of Tankyrase 1 (IC50=11nM) and Tankyrase 2 (IC50=4nM). Inhibition of tankyrase promotes stabilization of axin resulting in β-catenin degradation and Wnt signalling disruption. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells.

Product Specification

Alternative Name:3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
 
Formula:C14H11F3N2OS
 
MW:312.3
 
CAS:284028-89-3
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (20 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Solutions can be stored at -20°C for up to 3 months.
 
BML-WN100 Structure
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BML-WN100 Structure

Product Literature References

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling: S. Huang, et al.; Nature 461, 614 (2009), Abstract;

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