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IκBα (human), (recombinant) (GST-tag)

BML-UW9970-0050 50 µg 204.00 USD
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Product Specification

MW:61.9 kDa
Source:Produced in E. coli.
UniProt ID:P25963
Formulation:Liquid. In 50mM HEPES, pH 7.5, 200mM NaCl, 1mM DTT.
Purity:≥95% (SDS-PAGE)
Purity Detail:Purified by glutathione affinity chromatography.
Application Notes:Uses:
1. NF-κB pathway studies, inhibition of NF-κB p50/p65, substrate for IκB kinase (IKK).
2.Investigation of IκBa phosphorylation/ubiquitinylation/SUMOylation.
3. Ubiquitin-proteasome mediated degradation studies.
4.GST pull down of IκBa interacting partners
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Scientific Background:IκBa inhibits activation of the NF-κB pathway activation by associating with the major NF-κB heterodimeric complex p50/p65 and preventing its translocation from the cytoplasm into the nucleus, where it acts a transcription factor for genes involved in inflammation, autoimmune response, cell proliferation, and apoptosis. Inhibition of NF-κB pathway activation by IκBa is controlled by its sequential serine-phosphorylation, ubiquitination and proteasomal degradation. This process itself can be inhibited by SUMOylation of IκBa, providing an additional regulatory step for the activation of the NF-κB pathway.

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For Research Use Only. Not for use in diagnostic procedures.
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