IκBα (human), (recombinant) (GST-tag)

Source/Host:	Produced in E. coli.

Application:	1. NF-κB pathway studies, inhibition of NF-κB p50/p65, substrate for IκB kinase (IKK). 2.Investigation of IκBa phosphorylation/ubiquitinylation/SUMOylation. 3. Ubiquitin-proteasome mediated degradation studies. 4.GST pull down of IκBa interacting partners.

Long Term Storage:	-80°C

Miscellaneous/General:	IκBa inhibits activation of the NF-κB pathway activation by associating with the major NF-κB heterodimeric complex p50/p65 and preventing its translocation from the cytoplasm into the nucleus, where it acts a transcription factor for genes involved in inflammation, autoimmune response, cell proliferation, and apoptosis. Inhibition of NF-κB pathway activation by IκBa is controlled by its sequential serine-phosphorylation, ubiquitination and proteasomal degradation. This process itself can be inhibited by SUMOylation of IκBa, providing an additional regulatory step for the activation of the NF-κB pathway.

Background / Technical Information:	Please click here for the comprehensive product datasheet.