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PIAS1 (human), (recombinant) (GST-tag)

 
BML-UW9960-0025 25 µg 175.00 USD
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Product Specification

Alternative Name:Protein inhibitor of activated STAT protein 1, SUMO E3 ligase PIAS1
 
MW:~70 kDa
 
Source:Produced in E. coli.
 
UniProt ID:O75925
 
Formulation:Liquid. In 50mM Na-phosphate, pH 7.5, 200mM NaCl.
 
Purity:≥95% (SDS-PAGE)
 
Purity Detail:Purified by glutathione affinity chromatography.
 
Biological Activity:Exhibits SUMO modification activity in vitro.
 
Application Notes:For use in SUMO modification reactions and SUMOylation pathway studies.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:PIAS1 is a SUMO E3 ligase with specificity for a range of different substrates including p53, Hdm2, transcription factors, androgen receptors and co-repressor proteins.
 

Product Literature References

Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors: A.M. Jaeger, et al.; Nat. Struct. Mol. Biol. 23, 147 (2016), Application(s): Used in in vitro SUMOylation assays, Abstract;

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