USP2 (catalytic domain) (rat), (recombinant) (untagged)

Alternative Name:	Ubiquitin-specific protease 2

Source/Host:	Produced in E. coli. Untagged USP2 catalytic domain.

Application:	Deubiquitinylation assays using small molecule substrates (e.g. Ub-AMC) or ubiquitin-protein conjugates. Studies of the interaction of USP2 with FAS1 and their role in prostate cancer. Development of inhibitors for USP2 deubiquitinylating activity.

Long Term Storage:	-80°C

Miscellaneous/General:	USP2 is a ubiquitin-specific protease thought to function at the pre-proteasomal level by preventing the degradation of fatty acid synthase (FAS). FAS overexpression occurs in the majority of epithelial tumors, including prostate cancer, and protects cancer cells from apoptosis. Because USP2 is overexpressed in prostate cancer and its inhibition results in apoptosis of transformed prostatic cells, this isopeptidase is a potential target for induction of apoptosis in prostate cancer cells. The N-terminal region (residues 271-618) of USP2 contains all the necessary residues for catalysis and exhibits deubiquitinylating activity vs. ubiquitin-AMC.

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