USP2 (rat) (recombinant) (Catalytic Domain) - Enzo Life Sciences

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BML-UW9850

Revised 01-Feb-10

USP2 (rat) (recombinant) (Catalytic Domain)
PRODUCT LINE	Ubiquitin & Ubl Signalling
PRODUCT CATEGORY	Ubiquitin-deconjugating Enzymes

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
BML-UW9850-0100		100 µg	208.00 USD

Product Specification

SOURCE/HOST:	Produced in E. coli. Untagged USP2 catalytic domain.
APPLICATION:	Deubiquitinylation assays using small molecule substrates (e.g. Ub-AMC) or ubiquitin-protein conjugates. Studies of the interaction of USP2 with FAS1 and their role in prostate cancer. Development of inhibitors for USP2 deubiquitinylating activity.
SHIPPING:	SHIPPED ON DRY ICE
LONG TERM STORAGE:	-80°C

General Information

USP2 is a ubiquitin-specific protease thought to function at the pre-proteasomal level by preventing the degradation of fatty acid synthase (FAS). FAS overexpression occurs in the majority of epithelial tumors, including prostate cancer, and protects cancer cells from apoptosis. Because USP2 is overexpressed in prostate cancer and its inhibition results in apoptosis of transformed prostatic cells, this isopeptidase is a potential target for induction of apoptosis in prostate cancer cells. The N-terminal region (residues 271-618) of USP2 contains all the necessary residues for catalysis and exhibits deubiquitinylating activity vs. ubiquitin-AMC.
BACKGROUND/TECHNICAL INFORMATION
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Further Categories Containing This Product:

Recombinant Proteins / Fusion Proteins

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