RanGAP1 fragment (human), (recombinant) (GST-tag)

Source/Host:	Produced in E. coli.

Application:	RanGAP1 acts as a very good control substrate for use in SUMOylation assays producing a product with a single SUMO modification as shown above.

Long Term Storage:	-80°C

Miscellaneous/General:	RanGTPase-activating RanGAP1 was the first protein shown to be post-translationally modified with SUMO. In higher eukaryotes, the cellular localization of RanGAP1 is regulated by SUMOylation of its C-terminal domain. The target lysines of RanGAP1, as well as the C-terminus of mature SUMO-1, lie within mobile regions of the two proteins. Upon SUMOylation, RanGAP1 and SUMO-1 behave as “beads-on-a-string” joined by a flexible isopeptide tether and their structures and local dynamic features do not change significantly beyond the site of this covalent linkage.

Background / Technical Information:	Please click here for the comprehensive product datasheet.