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hHR6B (human), (recombinant) (His-tag)

 
BML-UW9640-0100 100 µg 256.00 USD
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Ubiquitin-conjugating DNA repair enzyme.

Product Specification

Alternative Name:UbcH2B, Ubiquitin conjugating enzyme E2 B
 
MW:17.3 kDa
 
Source:Produced in E. coli.
 
UniProt ID:P63146
 
Formulation:Liquid. In 50mM HEPES, pH 8.0, 50mM NaCl, 10% glycerol, 1mM DTT.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:The family of UBC enzymes plays a central role in the ubiquitin pathway. Genetic studies with the S. cerevisiae Rad6 protein demonstrate a pleiotropic phenotype, including defects in DNA repair, proteolysis of N-end rule protein substrates, cellular proliferation, cell cycle progression and an inability to sporulate , which are all dependent on its ubiquitin-conjugating activity. In mice and humans, two homologues of RAD6 have been identified - hHR6A (homologue of RAD6A) and hHR6B (homologue of RAD6B) . Inactivation of the hHR6B-homologous gene in mice causes male infertility, which strongly implicates hHR6-dependent ubiquitinylation in chromatin remodeling.
 

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