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hHR6A (human), (recombinant) (His-tag)

 
BML-UW9635-0100 100 µg 256.00 USD
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Ubiquitin-conjugating DNA repair enzyme.

Product Specification

Alternative Name:UbcH2A, Ubiquitin conjugating enzyme E2 A
 
MW:17.3 kDa
 
Source:Produced in E. coli.
 
UniProt ID:P49459
 
Formulation:Liquid. In 50mM HEPES, pH 8.0, containing 50mM sodium chloride, 10% glycerol and 1mM DTT.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:The family of UBC enzymes plays a central role in the ubiquitin pathway. Genetic studies with the S.cerevisiae Rad6 protein demonstrate a pleiotropic phenotype, including defects in DNA repair, proteolysis of N-end rule protein substrates, cellular proliferation, cell cycle progression and an inability to sporulate, which are all dependent on its ubiquitin-conjugating activity. Rad6 can ubiquitinylate histones in vitro, and ubiquitinylation of histone H2B in S. cerevisiae is Rad6 dependent. In mice and humans, two homologues of RAD6 have been identified - hHR6A (homologue of RAD6A) and hHR6B (homologue of RAD6B). UbcH2A is phosphorylated in vitro by CDK-1 and -2 on serine residue 120, which is conserved in all hHR6A homologs, leading to an increase in the ubiquitin-conjugating activity of this enzyme.
 

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