hHR23B-derived UBA2 domain, (agarose immobilized)

Source/Host:	The synthetic hHR23B UBA2 domain has been covalently bonded to an agarose matrix at an approximate concentration of 2mg peptide per ml of settled matrix

Application:	Useful for immunoprecipitation and affinity purification of multi-ubiquitinylated proteins and mixtures of ubiquitin-conjugates.

Long Term Storage:	+4°C

Miscellaneous/General:	hHR23B is the human homologue of the yeast protein RAD23. hHR23B is known to participate in DNA repair by stabilizing Xeroderma pigmentosum group C protein. However hHR23B may also have important functions related to general proteolysis. hHR23B consists of an N-terminal ubiquitin-like (UbL), ubiquitin association 1 (UBA1), Xeroderma pigmentosum group C binding and UBA2 domains. The UBA domains interact with ubiquitin and inhibit the assembly of polyubiquitin whilst the UbL domain interacts with the poly-ubiquitin binding site 2 (PUbS2) domain of the S5A protein, which can carry polyubiquitinylated substrates into the proteasome.

Background / Technical Information:	Please click here for the comprehensive product datasheet.