UbcH5a (human), (recombinant) (His-tag)

Source/Host:	Produced in E. coli.

Application:	Useful for in vitro ubiquitinylation reactions. The His-tagged version of this enzyme is not susceptible to self-ubiquitinylation, which can occur with GST-tagged versions.

Long Term Storage:	-80°C

Miscellaneous/General:	UbcH5a is highly homologous to the S. cerevisiae Ubc4/5 family of E2 enzymes demonstrated to be essential for degradation of regulatory and abnormal proteins. UbcH5a, together with UbcH5b and UbcH5c, are the most active class of E2 enzymes in cell extracts and are associated with regulation of a number of transcription factors. Specifically, UbcH5a stimulates the conjugation of ubiquitin to the tumor suppressor p532.

Background / Technical Information:	Please click here for the comprehensive product datasheet.