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SUMO-4 (human), (recombinant) (His-tag)

 
BML-UW0905-0100 100 µg 134.00 USD
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Product Specification

Alternative Name:Small ubiquitin-related modifier 4
 
MW:~12.5kDa
 
Source:Produced in E. coli.
 
UniProt ID:Q6EEV6
 
Formulation:Liquid. In 20mM HEPES, pH 8.0, containing 1mM DTT.
 
Purity:≥90% (SDS-PAGE)
 
Purity Detail:Purified by multistep chromatography.
 
Application Notes:For use in SUMO-4 conjugation studies.
 
Shipping:Shipped on Dry Ice
 
Short Term Storage:-80°C
 
Long Term Storage:-80°C
 
Use/Stability:Stable for at least 12 months after receipt when stored at -80°C. 
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
 
Scientific Background:SUMO-4 is a member of the SUMO (small ubiquitin-related modifier) family of ubiquitin-like proteins involved in the regulation of the cellular functions of a wide variety of proteins, although there remains considerable debate as to whether this is a real and expressed gene product.

It has been reported that upon oxidative stress, SUMO-4 conjugates to various anti-oxidant enzymes, chaperones, and stress defence proteins, whereas under standard physiological conditions it is rapidly degraded. Subsequent proteomic analysis of SUMO-4 conjugates identified substrates implicated in the regulation of DNA repair and synthesis, RNA processing, protein degradation and glucose metabolism, suggesting a role for SUMO-4 in the regulation of intracellular stress.

The M55V substitution in SUMO-4 has been associated with type I diabetes.
 
BML-UW0905
SDS-PAGE image of His6-SUMO4 (1.5µg, BML-UW0905), coomassie stained.
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BML-UW0905

General Literature References

A stress-dependent SUMO4 sumoylation of its substrate proteins: W. Wei, et al.; BBRC 375, 454 (2008), Abstract;
SUMO4 and its role in type 1 diabetes pathogenesis: C.Y. Wang & J.X. She; Diabetes Metab. Res. Rev. 24, 93 (2008), Abstract;
Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress: D. Guo, et al.; BBRC 337, 1308 (2005), Abstract;
SUMO, ubiquitin's mysterious cousin: S. Muller, et al.; Nat. Rev. Mol. Cell Biol. 2, 202 (2001), Abstract;

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