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Ubiquitin-protein conjugates polyclonal antibody

 
BML-UG9511-0025 25 µl 89.00 USD
 
BML-UG9511-0100 100 µl 345.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: BML-UG9510

Product Specification

Host:Rabbit
 
Immunogen:Recombinant full length human ubiquitin protein.
 
UniProt ID:P0CG47 (UBB), P0CG48 (UBC), P62979 (RPS27A), P62987 (UBA52)
 
Species reactivity:Species independent
 
Specificity:Recognizes ubiquitin-protein conjugates and free ubiquitin. Human tested, other species based on homology.
 
Applications:IHC, WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections, 1:100)
Western Blot (1:100)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Liquid. In PBS, pH 7.6, containing 1% BSA and less than 0.1% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Ubiquitin (Ub) plays a very important role in regulated non-lysosomal ATP dependent protein degradation. The protein to be degraded is conjugated to Ub and the ubiquinated protein is then selectively degraded by a 26S complex, multicatalytic cytosolic and nuclear protease termed proteasome. The Ub-proteasome proteolytic pathway, which is a complex process, is implicated to be of great importance for regulating numerous cellular processes.
 
BML-UG9511 WB
Western blot analysis of Ubiquitin-protein conjugates, pAb (Prod. No. BML-UG9511-0100): Lane 1: MW marker, Lane 2: Poly-ubiquitin chains (Ub2-7) (K48-linked) (Prod. No. BML-UW8860).

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BML-UG9511 WB

General Literature References

Neuropathology of primary adult-onset dystonia: J. L. Holton et al.; Neurology 70, 695 (2008), Abstract;
Ubiquitination: D. Finley, et al.; Annu. Rev. Cell. Biol. 7, 25 (1991), Abstract;
Ubiquitin conjugate immunoreactivity in the brains of scrapie infected mice: J. S. Loewe, et al.; J. Pathol. 162, 61 (1990), Abstract;
Ubiquitinated protein conjugates are specifically enriched in the lysosomal system of fibroblasts: L. Laszlo, et al.; FEBS Lett. 261, 365 (1990), Abstract;
A filamentous inclusion body within anterior horn neurones in motor neurone disease defined by immunocytochemical localisation of ubiquitin: J. S. Lowe, et al.; Neurosci Lett 94, 203 (1988), Abstract;
Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson’s disease, Pick’s disease, and Alzheimer’s disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease: J. S. Lowe, et al.; J. Pathol. 155, 9 (1988), Abstract;
The immunochemical detection and quantitation of intracellular ubiquitin-protein conjugates: A. L. Haas et al.; J. Biol. Chem. 260, 12464 (1985), Abstract;
Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85: A. Ciechanover, et al.; Cell 37, 57 (1984), Abstract;

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