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Wiskostatin

Blocks actin filament assembly
 
BML-T126-0001 1 mg 66.00 USD
 
BML-T126-0005 5 mg 270.00 USD
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A selective, reversible inhibitor of N-WASP (neural Wiskott-Aldrich syndrome protein) that selectively blocks actin filament assembly. Appears to bind to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex.

Product Specification

MW:426.15
 
CAS:253449-04-6
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white solid.
 
MeltingPoint:148-150°C
 
Solubility:Soluble in ethanol (10 mg/ml with warming) or DMSO (25 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
 
BML-T126 structure
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BML-T126 structure

Product Literature References

Neural Wiskott-Aldrich syndrome protein (nWASP) is implicated in human lung cancer invasion: B.A. Frugtniet, et al.; BMC Cancer 17, 224 (2017), Abstract; Full Text
WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion: E. Garcia, et al.; Sci. Rep. 6, 23590 (2016), Application(s): Cell culture, Abstract; Full Text

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For Research Use Only. Not for use in diagnostic procedures.
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