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Swinholide A

Disrupts actin cytoskeleton
 
BML-T125-0020 20 µg Inquire for pricing
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Replaces Prod. #: ALX-350-088

Cytotoxic agent which disrupts actin cytoskeleton in cultured cells. Sequesters and stabilizes actin dimers in vivo with a 1:1 binding stoichiometry and rapidly severs actin filaments with high cooperativity.

Product Specification

Formula:C78H132O20
 
MW:1389.9
 
Source:Isolated from marine sponge Theonella swinhoei.
 
CAS:95927-67-6
 
Formulation:Liquid. In DMSO.
 
Purity:≥98% (TLC)
 
Solubility:Soluble in DMSO.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C.
 
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Product Literature References

Hurghadolide A and swinholide I, potent actin-microfilament disrupters from the Red Sea sponge Theonella swinhoei: D.T. Youssef & S.L. Mooberry; J. Nat. Prod. 69, 154 (2006), Abstract;
Structural basis of swinholide A binding to actin: V.A. Klenchin, et al.; Chem. Biol. 12, 287 (2005), Abstract;
Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A: S.Y. Saito, et al.; J. Biochem. 123, 571 (1998), Abstract;
Use of the F-actin-binding drugs, misakinolide A and swinholide A: M.R. Bubb & I. Spector; Methods Enzymol. 298, 26 (1998), Abstract;
Autoregulation of actin synthesis responds to monomeric actin levels: A. Lyubimova, et al.; J. Cell. Biochem. 65, 469 (1997), Abstract;
Misakinolide A is a marine macrolide that caps but does not sever filamentous actin: D.R. Terry, et al.; J. Biol. Chem. 272, 7841 (1997), Abstract; Full Text
Two classes of metabolites from Theonella swinhoei are localized in distinct populations of bacterial symbionts: C.A. Bewley, et al.; Experientia 52, 716 (1996), Abstract;
Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments: M.R. Bubb, et al.; J. Biol. Chem. 270, 3463 (1995), Abstract; Full Text
Marine natural products. XXXI. Structure-activity correlation of a potent cytotoxic dimeric macrolide swinholide A, from the Okinawan marine sponge Theonella swinhoei, and its isomers: M. Kobayashi, et al.; Chem. Pharm. Bull. (Tokyo) 42, 19 (1994), Abstract;
Marine natural products. XXIII. Three new cytotoxic dimeric macrolides, swinholides B and C and isoswinholide A, congeners of swinholide A, from the Okinawan marine sponge Theonella swinhoei: M. Kobayashi, et al.; Chem. Pharm. Bull. (Tokyo) 38, 2960 (1990), Abstract;

General Literature References

Makrolide aus marinen Organismen: G. Schilling; Labor&more 1.12, 32 (2012),

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