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Mycalolide B

Depolymerizes actin
 
BML-T123-0020 20 µg 297.00 USD
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Replaces Prod. #: ALX-350-288

Mycalolide B is a novel marine natural product which binds to actin in a 1:1 molar ratio (Kd=13-20 nM). It selectively and completely depolymerizes F-actin to G-actin via a mechanism distinct from that of the cytochalasins. Unlike cytochalasins, it inhibits actin-activated Mg2+-ATPase from rabbit skeletal muscle.

Product Specification

Formula:C52H74N4O17
 
MW:1027.2
 
Source:Isolated from the marine sponge Mycale sp.
 
CAS:122752-21-0
 
Purity:≥98% (HPLC)
 
Appearance:Clear to white solid
 
Solubility:Soluble in DMSO, methanol or isopropanol
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
350-288
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350-288

Product Literature References

Actin filaments play an essential role for transport of nascent HIV-1 proteins in host cells: H. Sasaki et al.; Biochem. Biophys. Res. Commun. 316, 588 (2004), Abstract;
Uncoupling of gate and fence functions of MDCK cells by the actin-depolymerizing reagent mycalolide B: R. Takakuwa; Exp. Cell. Res. 257, 238 (2000), Abstract;
Actin-binding specificity of marine macrolide toxins, mycalolide B and kabiramide D: S. Wada et al.; J. Biochem. 123, 946 (1998), Abstract;
Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A: S.Y. Saito, et al.; J. Biochem. 123, 571 (1998), Abstract;
Inhibition of rat platelet aggregation by mycalolide-B, a novel inhibitor of actin polymerization with a different mechanism of action from cytochalasin-D: A. Sugidachi et al.; Thromb. Haemost. 79, 614 (1998), Abstract;
A family of novel actin-inhibiting marine toxins: S. Saito & H. Karaki ; Clin. Exp. Pharmacol. Physiol. 23, 743 (1996), Abstract;
Cellular changes of rat embryonic fibroblasts by an actin-polymerization inhibitor, bistheonellide A, from a marine sponge: S. Watabe et al.; Cell. Struct. Funct. 21, 199 (1996), Abstract;
Mycalolide B, a novel actin depolymerizing agent: S.Saito et al.; J. Biol. Chem. 269, 29710 (1994), Abstract;
Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge: M. Hori et al.; FEBS Lett. 322, 151 (1993), Abstract;

General Literature References

Makrolide aus marinen Organismen: G. Schilling; Labor&more 1.12, 32 (2012),

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