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Vincristine . sulfate

Microtubule inhibitor
BML-T117-0005 5 mg 118.00 USD
BML-T117-0025 25 mg 466.00 USD
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Replaces Prod. #: ALX-350-069

Plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Depolymerizes microtubules and blocks binding of tubulin to microtubule proteins. Causes aberrant tubulin polymerization. Induces apoptosis. Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression. Cancer chemotherapeutic agent. Posttranscriptionally downregulates HIF-1α expression.

Product Specification

Alternative Name:VCR . sulfate, Leukocristine . sulfate
Formula:C46H56N4O10 . H2SO4
MW:825.0 . 98.1
MI:14: 9986
Purity:≥98% TLC
Appearance:White to off-white powder.
Solubility:Soluble in water (25mg/ml) or methanol.
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling:Protect from light and moisture.
Technical Info/Product Notes:Note: Product is not sterile.
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Product Literature References

Co-treatment with Celecoxib or NS398 Strongly Sensitizes Resistant Cancer Cells to Antimitotic Drugs Independent of P-gp Inhibition: J.S. Lim, et al.; Anticancer Res. 36, 5063 (2016), Application(s): Cell Treatment, Abstract; Full Text
Selenate specifically sensitizes drug-resistant cancer cells by increasing apoptosis via G2 phase cell cycle arrest without P-GP inhibition: A.R. Choi, et al.; Eur. J. Pharmacol. 764, 63 (2015), Application(s): Cell Culture, Abstract;
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF: N.J. Mabjeesh, et al.; Cancer Cell 3, 363 (2003), Abstract;
Selective toxicity of vincristine against chronic lymphocytic leukemia cells in vitro: J.A. Vilpo, et al.; Eur. J. Haematol. 65, 370 (2000), Abstract;
Vincristine-induced apoptosis in vivo in peripheral blood mononuclear cells of children with acute lymphoblastic leukaemia (ALL): E. Groninger, et al.; Br. J. Haematol. 111, 875 (2000), Abstract;
The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review: L.G. Wang, et al.; Cancer Chemother. Pharmacol. 44, 355 (1999), (Review), Abstract;
Bcl-xL is phosphorylated in malignant cells following microtubule disruption: M.S. Poruchynsky, et al.; Cancer Res. 58, 3331 (1998), Abstract;
Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle: A. Jordan, et al.; Med. Res. Rev. 18, 259 (1998), Abstract;
Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death: M.V. Blagosklonny, et al.; Cancer Res. 57, 130 (1997), Abstract;
Antimitotic natural products and their interactions with tubulin: E. Hamel; Med. Res. Rev. 16, 207 (1996), Abstract;
Bcl-2 interrupts the ceramide-mediated pathway of cell death: J. Zhang, et al.; PNAS 93, 5325 (1996), Abstract;
Interaction of vinca alkaloids with tubulin: a comparison of vinblastine, vincristine, and vinorelbine: S. Lobert, et al.; Biochemistry 35, 6806 (1996), Abstract;
Binding selectivity of rhizoxin, phomopsin A, vinblastine, and ansamitocin P-3 to fungal tubulins: differential interactions of these antimitotic agents with brain and fungal tubulins [published erratum appears in BBRC 190, 1180 (1993)]: Y. Li, et al.; BBRC 187, 722 (1992), Abstract;
Cell death induced by vincristine in the intestinal crypts of mice and in a human Burkitt's lymphoma cell line: B.V. Harmon, et al.; Cell Prolif. 25, 523 (1992), Abstract;
Interactions of the catharanthus (Vinca) alkaloids with tubulin and microtubules: R.H. Himes; Pharmacol. Ther. 51, 257 (1991), Abstract;

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