Replaces Prod. #: ALX-350-036
Structurally unique marine toxin. Actin filament modulator. 10- to 100-fold more potent than cytochalasins. Whereas cytochalasin D (Prod. No. BML-T109) induces dissolution of F-actin and stress fiber contraction in fibroblasts in culture, latrunculin B causes a shortening and thickening of stress fibers. Effects on N1E-115 cells (mouse neuroblastoma) at concentrations as low as 90nM (NI43T3 cells, 0.9µM). Maximum effects at 2.5µM. Slowly inactivated by fetal bovine serum. Inhibition of cofilin-actin binding (ED50~50µM)
Product Specification
Formula: | C20H29NO5S |
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MW: | 395.5 |
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Source: | Isolated from Latrunculia magnifica. |
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CAS: | 76343-94-7 |
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MI: | 14: 5378 |
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Purity: | ≥98% (HPLC) |
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Appearance: | Lyophilized solid. |
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Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). |
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Shipping: | Ambient |
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Long Term Storage: | -20°C |
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Product Literature References
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Abstract;
Full Text
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Full Text
Histones trigger sterile inflammation by activating the NLRP3 inflammasome: R. Allam, et al.; Eur. J. Immunol.
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Full Text
Isolation and characterization of cytoplasmic cofilin-actin rods: L.S. Minamide, et al.; J. Biol. Chem.
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Abstract;
The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2, but is dependent on an intact actin cytoskeleton as determined by FRAP: B. Cha, et al.; J. Cell Sci.
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Abstract;
Full Text
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Abstract;
Latrunculins--novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D: I. Spector, et al.; Cell Motil. Cytoskeleton
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Abstract;
Latrunculin A is a potent inhibitor of phagocytosis by macrophages: C.A. de Oliveira & B. Mantovani; Life Sci.
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Abstract;
Inhibition of actin polymerization by latrunculin: M. Coue, et al.; FEBS Lett.
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Abstract;
Latrunculin inhibits the microfilament-mediated processes during fertilization, cleavage and early development in sea urchins and mice: G. Schatten, et al.; Exp. Cell. Res.
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Abstract;
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Abstract;
General Literature References
Makrolide aus marinen Organismen: G. Schilling; Labor&more 1.12, 32 (2012),
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