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N1, N12-Diethylspermine . tetrahydrochloride

Inhibits polyamine synthesis
 
BML-T105-0010 10 mg 131.00 USD
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Replaces Prod. #: ALX-430-037

Potent antineoplastic activity. Inhibits polyamine synthesis and the synthesis of mitochnondrial DNA.

Product Specification

Formula:C14H34N4 . 4HCl
 
MW:404.3
 
CAS:113812-15-0
 
Purity:≥98% (TLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:White crystalline solid.
 
Solubility:Soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
430-037
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430-037

Product Literature References

Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function: P.M. Vertino, et al.; Mol. Pharmacol. 39, 487 (1991), Abstract;
Combined regulation of ornithine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1 N12-bis(ethyl)spermine: C.W. Porter, et al.; Biochem. J. 268, 207 (1990), Abstract;
High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma: R.A. Casero Jr., et al.; Biochem. J. 270, 615 (1990), Abstract; Full Text
Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N1N8-bis(ethyl)spermidine: C.W. Porter, et al.; Biochem. J. 242, 433 (1987), Abstract;
Relative abilities of bis(ethyl) derivatives of putrescine, spermidine, and spermine to regulate polyamine biosynthesis and inhibit L1210 leukemia cell growth: C.W. Porter, et al.; Cancer Res. 47, 2821 (1987), Abstract;

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