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Nocodazole

Microtubule inhibitor
 
BML-T101-0010 10 mg 90.00 USD
 
BML-T101-0050 50 mg 370.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-430-029

Synthetic reversible microtubule inhibitor.

Product Specification

Alternative Name:Methyl[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate, R 17934
 
Formula:C14H11N3O3S
 
MW:301.3
 
CAS:31430-18-9
 
Purity:≥98% (HPLC)
 
Appearance:Solid. White, off-white, orange and possibly even a brown/pink color.
 
Solubility:Soluble in DMSO (10mg/ml) or dimethyl formamide; almost insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

The Budding Yeast Ubiquitin Protease Ubp7 is a Novel Component Involved in S-phase Progression: S. Bohm, et al.; J. Biol. Chem. 291, 4442 (2016), Application(s): Cell culture, Abstract; Full Text
Epithelial sphingolipid sorting is insensitive to reorganization of the Golgi by nocodazole, but is abolished by monensin in MDCK cells and by brefeldin A in Caco-2 cells: G. van Meer & W. van 't Hof; J. Cell Sci. 104, 833 (1993), Abstract;
Possible involvement of microtubules in platelet-activating factor-induced increases in microvascular permeability in vitro: A.M Northover & B.J. Northover; Inflammation 17, 633 (1993), Abstract;
Role of microtubules in transferrin receptor transport from the cell surface to endosomes and the Golgi complex: M. Jin & M.D. Snider; J. Biol. Chem. 268, 18390 (1993), Abstract;
Interaction of oncodazole (R 17934), a new antitumoral drug, with rat brain tubulin: J. Hoebeke, et al.; BBRC 69, 319 (1976), Abstract;
The effects of methyl (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl) carbamate, (R 17934; NSC 238159), a new synthetic antitumoral drug interfering with microtubules, on mammalian cells cultured in vitro: M.J. De Brabander, et al.; Cancer Res. 36, 905 (1976), Abstract;
R17934-NSC 238159: a new antitumor drug--I. Effect on experimental tumors and factors influencing effectiveness: G. Atassi & H.J. Tagnon; Eur. J. Cancer 11, 599 (1975), Abstract;
R17934-NSC238159: a new antitumor drug--II. Effect on mitotic cycle of L1210 leukemia cells in vivo and synergism with cytosine arabinoside (NSC63878): G. Atassi, et al.; Eur. J. Cancer 11, 609 (1975), Abstract;

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