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PI3 kinase inhibitor
BML-ST415-0001 1 mg 59.00 USD
BML-ST415-0005 5 mg 234.00 USD
BML-ST415-0020 20 mg 444.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: ALX-350-020

Potent and selective inhibitor of phosphatidyl-inositol 3-kinase. Active in purified preparations and cytosolic fractions(IC50 = 5nM) and is highly cell permeable. Inhibits fMLP induced PIP3 and superoxide anion production (IC50 = 50nM) in guinea pig neutrophils and blocks the metabolic effects of insulin in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Covalently binds to PI 3-kinase and is selective, inhibiting other kinases such as PI 4-kinase and myosin light chain kinase at concentrations 100-fold higher than that required for inhibition of PI 3-kinase. The half-life of wortmannin in culture media is quite short (8-13 minutes), care should be taken to account for this decomposition when planning experiments. Markedly potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau.

Product Specification

Alternative Name:KY 12420
Source:Isolated from Penicillium wortmannii
MI:14: 10053
Purity:≥98% (HPLC, TLC)
Appearance:White to off-white solid.
Solubility:Soluble in DMSO (50mg/ml), methanol (5mg/ml) or 100% ethanol (25mg/ml).
Long Term Storage:-20°C
Use/Stability:Make solutions fresh immediately before use. DO NOT STORE SOLUTIONS.
Technical Info/Product Notes:Replacement for ADI-HPK-114.
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Product Literature References

Additive effects of low concentrations of estradiol-17β and progesterone on nitric oxide production by human vascular endothelial cells through shared signaling pathways: Y. Pang & P. Thomas; J. Steroid Biochem. Mol. Biol. 165, 258 (2017), Application(s): Effects of steroids and inhibitors on NO production, Abstract;
Neutrophils Discriminate between Lipopolysaccharides of Different Bacterial Sources and Selectively Release Neutrophil Extracellular Traps: E. Pieterse, et al.; Front. Immunol. 7, 484 (2016), Abstract; Full Text
Tumour-necrosis factor-α induces heparan sulfate 6-O-endosulfatase 1 (Sulf-1) expression in fibroblasts: A.S. Sikora, et al.; Int. J. Biochem. Cell Biol. 80, 57 (2016), Application(s): Treatment of MRC-5 cells , Abstract;
Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl: D. Manganaro, et al.; Biochim. Biophys. Acta 1853, 1879 (2015), Application(s): Cell Culture, Abstract;
African swine fever virus infects macrophages, the natural host cells, via clathrin- and cholesterol-dependent endocytosis: I. Galindo, et al.; Virus Res. 200, 45 (2015), Application(s): Cell Culture, Abstract;
Role for Artemis nuclease in the repair of radiation-induced DNA double strand breaks by alternative end joining: M. Moscariello, et al.; DNA Repair (Amst.) 31, 29 (2015), Application(s): Cell Culture, Abstract;
bis-Dehydroxy-Curcumin Triggers Mitochondrial-Associated Cell Death in Human Colon Cancer Cells through ER-Stress Induced Autophagy: V. Basile, et al.; PloS One 8, e53664 (2013), Application(s): WB, IF, PCR, Abstract; Full Text
Cornel Iridoid Glycoside Attenuates Tau Hyperphosphorylation by Inhibition of PP2A Demethylation: C.C. Yang, et al.; Evid. Based Complement. Alternat. Med. 2013, 108486 (2013), Application(s): IC, WB, Abstract; Full Text
Insulin stimulates translocation of human GLUT4 to the membrane in fat bodies of transgenic Drosophila melanogaster: G. Crivat, et al.; PloS One 8, e77953 (2013), Application(s): Fluorescence Microscopy, Abstract; Full Text
TR3 modulates platinum resistance in ovarian cancer: A.J. Wilson, et al.; Cancer Res. 73, 4758 (2013), Application(s): WB, IF, IHC, Abstract; Full Text
Anaphylaxis to cow's milk formula containing short-chain galacto-oligosaccharide: W.C. Chiang, et al.; J. Allergy Clin. Immunol. 130, 1361 (2012), Application(s): Flow Cytometry, Abstract;
Enhanced contractility and myosin phosphorylation induced by Ca2+-independent MLCK activity in hypertensive rats: Y.E. Cho, et al.; Cardiovasc. Res. 91, 162 (2011), Application(s): IF, Abstract; Full Text
Induction of steroid sulfatase expression by tumor necrosis factor-α through phosphatidylinositol 3-kinase/Akt signaling pathway in PC-3 human prostate cancer cells: B.Y. Suh, et al.; Exp. Mol. Med. 43, 646 (2011), Application(s): WB, IF, PCR, Abstract; Full Text
Stimulus-specific blockade of nitric oxide-mediated dilatation by asymmetric dimethylarginine (ADMA) and monomethylarginine (L-NMMA) in rat aorta and carotid artery: M.J. Al-Zobaidy, et al.; Eur. J. Pharmacol. 673, 78 (2011), Application(s): Wortmannin effect on acetylcholine-induced relaxation of cardiac tissue, Abstract;
Chemistry and biology of wortmannin: P. Wipf & R.J. Halter; Org. Biomol. Chem. 3, 2053 (2005), Abstract;
Use of high-performance liquid chromatography to characterize the rapid decomposition of wortmannin in tissue culture media:: J.L. Holleran, et al.; Anal. Biochem. 323, 19 (2003), Abstract;
Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melatonin: S.J. Liu & J.Z. Wang; Acta Pharmacol. Sin. 23, 183 (2002), Abstract;
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes: E.F. Blommaart, et al.; Eur. J. Biochem. 243, 240 (1997), Abstract;
Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, enhances LPS-induced NO production from murine peritoneal macrophages: Y.C. Park, et al.; BBRC 240, 692 (1997), Abstract;
Inhibitory effect of wortmannin on phosphatidylinositol 3-kinase-mediated cellular events: O. Hazeki, et al.; J. Lipid Mediat. Cell Signal. 14, 259 (1996), Abstract;
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction: M.P. Wymann, et al.; Mol. Cell. Biol. 16, 1722 (1996), Abstract;
Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase: M. Ui, et al.; TIBS 20, 303 (1995), (Review), Abstract;
Wortmannin inhibits carcinogen-stimulated phosphorylation of ethanolamine and choline: Z. Kiss & M. Tomono; FEBS Lett. 358, 243 (1995), Abstract;
Wortmannin inhibits insulin-stimulated but not contraction-stimulated glucose transport activity in skeletal muscle: A.D. Lee, et al.; FEBS Lett. 361, 51 (1995), Abstract;
Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption: I. Nakamura, et al.; FEBS Lett. 361, 79 (1995), Abstract;
Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells: K. Tomiyama, et al.; BBRC 212, 263 (1995), Abstract;
A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase: R. Woscholski, et al.; FEBS Lett. 342, 109 (1994), Abstract;
Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase: T. Okada, et al.; J. Biol. Chem. 269, 3563 (1994), Abstract;
Effects of wortmannin on increased glucose transport by insulin and norepinephrine in primary culture of brown adipocytes: Y. Shimizu & T. Shimazu; BBRC 202, 660 (1994), Abstract;
Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin: T. Okada, et al.; J. Biol. Chem. 269, 3568 (1994), Abstract;
Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells: H. Yano, et al.; J. Biol. Chem. 268, 25846 (1993), Abstract; Full Text
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses: A. Arcaro & M.P. Wyman; Biochem. J. 296, 297 (1993), Abstract;
Inhibition of IgE-mediated histamine release by myosin light chain kinase inhibitors: S. Kitani, et al.; BBRC 183, 48 (1992), Abstract;
Wortmannin, a microbial product inhibitor of myosin light chain kinase: S. Nakanishi, et al.; J. Biol. Chem. 267, 2157 (1992), Abstract; Full Text
Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil: R.W. Bonser, et al.; Br. J. Pharmacol. 103, 1237 (1991), Abstract;
Activation of human neutrophil phospholipase D by three separable mechanisms: S.I. Reinhold, et al.; FASEB J. 4, 208 (1990), Abstract;

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