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Propranolol

Adrenergic receptor inhibitor
 
BML-ST405-0005 5 g 58.00 USD
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Propranolol blocks PLD derived DAG formation by inhibiting phosphatidate phosphohydrolase (IC50=70 µM). It is a useful tool to discriminate between PLC or PLD mediated DAG production. It is also a β-adrenergic receptor blocking agent.

Product Specification

Formula:C16H21NO2 . HCl
 
MW:295.8
 
CAS:318-98-9
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR and LC-MS.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
ST405 Propranolol
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ST405 Propranolol

Product Literature References

Receptor-coupled phospholipase D and its inhibition: N.T. Thompson, et al.; Trends Pharmacol. Sci. 12, 404 (1991), Abstract;
Regulation of phospholipase D in HL-60 granulocytes. Activation by phorbol esters, diglyceride, and calcium ionophore via protein kinase- independent mechanisms: M. M. Billah, et al.; J. Biol. Chem. 264, 9069 (1989), Abstract; Full Text
The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias: A. M. Barrett, et al.; Br. J. Pharmacol. 34, 43 (1968), Abstract; Full Text

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