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Methyl Arachidonyl Fluorophosphonate

Phospholipase inhibitor
BML-ST360-0005 5 mg 122.00 USD
BML-ST360-0025 25 mg 493.00 USD
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Replaces Prod. #: ALX-340-017

Selective, active-site directed, irreversible inhibitor of cPLA2 (IC50=5µM) and Ca2+-independent iPLA2 (IC50=0.5µM). Potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50=2.5nM), 800 -fold more potent than AACOCF3 (Prod. No. BML-ST335)). Irriversible CB1 receptor antagonist in rat brain membrane (IC50=20nM).

Product Specification

Alternative Name:MAFP, Methylphosphonofluoridic acid 5,8,11,14-eicosatetraenyl ester
Purity:≥98% (TLC)
Appearance:Colorless to yellow oil.
Solubility:Soluble in 100% ethanol (50mg/ml) or DMSO (50mg/ml).
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Use/Stability:Stable for at least 1 year after receipt when stored at -80°C. Stock solutions are stable for up to 2 months at -20°C.
Handling:Protect from air.
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Product Literature References

Evidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonist: S.R. Fernando & R.G.Pertwee; Br. J. Pharmacol. 121, 1716 (1997), Abstract;
Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase: D.G. Deutsch, et al.; Biochem. Pharmacol. 53, 255 (1997), Abstract;
Distinct roles in signal transduction for each of the phospholipase A2 enzymes present in P388D1 macrophages: J. Balsinde & E.A. Dennis; J. Biol. Chem. 271, 6758 (1996), Abstract; Full Text
Irreversible inhibition of Ca(2+)-independent phospholipase A2 by methyl arachidonyl fluorophosphonate: Y.C. Lio, et al.; Biochim. Biophys. Acta 1302, 55 (1996), Abstract;

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