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HELSS

Phospholipase inhibitor
 
BML-ST340-0005 5 mg 128.00 USD
 
BML-ST340-0025 25 mg 528.00 USD
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HELSS is a potent, irreversible, mechanism-based inhibitor of Ca2+-independent PLA2 (70% inhibition at 100 nM). It possesses a 1000-fold selectivity for Ca2+-independent PLA2 vs. Ca2+-dependent PLA2 . It has been used to identify the PLA2 involved in the release of arachidonate induced by vasopressin stimulation of A-10 smooth muscle cells (IC50=1 µM). It has also been shown to inhibit the Mg2+-dependent phophatidate phosphohydrolase from P388D1 macrophages (IC50~8 µM).

Product Specification

Alternative Name:Haloenol lactone suicide substrate
 
Formula:C16H13BrO2
 
MW:317.2
 
CAS:88070-98-8
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
MeltingPoint:104-106°C
 
Solubility:Soluble in DMSO (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions under at atmosphere of argon or nitrogen at -20°C for up to 1 month.
 
BML-ST340 structure
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BML-ST340 structure

Related Literature

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Arachidonic Acid Metabolites
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