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PACOCF3

Phospholipase inhibitor
 
BML-ST336-0010 10 mg 68.00 USD
 
BML-ST336-0050 50 mg 253.00 USD
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Replaces Prod. #: ALX-340-019

Inhibitor of both Ca2+-dependent cytosolic cPLA2 (IC50=45 µM) and Ca2+-independent phospholipases A2 iPLA2 (IC50=3.8 µM).

Product Specification

Alternative Name:Palmityl trifluoromethylketone, PTK
 
Formula:C17H31F3O
 
MW:308.4
 
CAS:141022-99-3
 
Purity:≥98% (TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in 100% ethanol, dimethyl formamide or DMSO (warm); sparingly soluble in neutral buffers.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C. Not stable in basic solutions (pH > 7.4). We do not recommend storing aqueous solutions for more than one day.
 
Technical Info/Product Notes:Note: Product is not sterile.
 
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Product Literature References

Activated ketones as inhibitors of intracellular Ca2+-dependent and Ca2+-independent phospholipase A: K. Conde-Friesboes, et al.; JACS 118, 5519 (1996),
Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones: E.J. Ackermann, et al.; J. Biol. Chem. 270, 445 (1995), Abstract; Full Text

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